Category: International EM
Keywords: Tuberculosis, infectious disease, drug resistance, multidrug resistant tuberculosis (PubMed Search)
Posted: 1/21/2015 by Jon Mark Hirshon, PhD, MPH, MD
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As noted previously (UMEM Pearl of 1/7/2015), tuberculosis (TB) is a major infectious disease that occurs worldwide. Strains of tuberculosis can be resistant to one or more anti-tuberculosis medications. TB strains resistant to at least one medication have been found in all surveyed countries.
What is multidrug-resistant tuberculosis (MDR TB)?
Treatment of MDR TB
Bottom line:
As noted previously, in your emergency department have a high index of suspicion for TB and MDR TB in patients with an appropriate risk profile.
http://www.who.int/mediacentre/factsheets/fs104/en/
http://www.cdc.gov/tb/topic/drtb/default.htm
http://www.cdc.gov/tb/publications/factsheets/drtb/mdrtb.htm
Category: Critical Care
Posted: 1/20/2015 by Haney Mallemat, MD
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Category: Visual Diagnosis
Posted: 1/19/2015 by Haney Mallemat, MD
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60 year-old male presents with 6 months of weight loss,epistaxis, and increased headache when bending over. What's the diagnosis?
SVC Syndrome
Rice TW, Rodriguez RM, Light RW. The superior vena cava syndrome: clinical characteristics and evolving etiology. Medicine (Baltimore). Jan 2006;85(1):37-42.
Nunnelee JD. Superior vena cava syndrome. J Vasc Nurs. Mar 2007;25(1):2-5
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Category: Pediatrics
Keywords: Trauma, pelvic fractures, imaging (PubMed Search)
Posted: 1/19/2015 by Jenny Guyther, MD
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Of pediatric patients who have anteroposterior (AP) pelvic xrays (XR), there is a 4.6% rate of pelvic fracture or dislocation, compared to 10% in adults.
This study is a sub analysis of a prospective observational cohort of children with blunt torso trauma conducted by PECARN. 7808 patients had pelvic imaging, with 65% of them having an AP XR. The XR sensitivity ranged from 64-82% (based on age groups) for detecting fractures. All but one patient with a pelvic fracture not detected on XR had a CT scan. The CT scan detected all but 2 fractures both of which were picked up later as healing fractures on repeat pelvic XR. Some of the patients who had a missed fracture on XR were hemodynamically unstable or wound up requiring operative intervention.
The authors support the following algorithm:
-With hemodynamically unstability children, obtain a pelvic XR
-For hemodynamically stable children when the physician is planning to get a CT, there is no indication for XR
Bottom line: Consider using AP pelvic radiographs in the hemodynamically stable patient with a high suspicion for fracture or dislocation who are not undergoing CT.
Kwok et al. Sensitivity of Plain Pelvis Radiography in Children with Blunt Torso Trauma. Annals of Emergency Medicine 2015; 65: 63-71.
Category: Cardiology
Posted: 1/18/2015 by Semhar Tewelde, MD
(Updated: 11/14/2024)
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Left Ventricular Hypertrophy & Arrhythmias: Any Association?
Associations between left ventricular hypertrophy (LVH) and both supraventricular (SVT)/ventricular arrhythmias (VT/VF) have previously been reported.
A recent review & meta-analysis of 10 studies (27,141 patients) revealed the following:
- Incidence of SVT was 11% with LVH compared to 1% without (p <0.001)
- LVH patients had 3.4-fold greater odds of developing SVT
- Incidence of VT/VF was 5.5% with LVH compared to 1.2% without (p <0.001)
- LVH patients has 2.8 greater odds of developing VT/VF
The reason for increased arrhythmogenicity in LVH is not clearly understood.
A consistently observed abnormality in LVH is non-uniform propagation of the action potential throughout the myocardium, which sets the stage for arrhythmias based on early or delayed afterdepolarizations.
Given the heterogeneity in this meta-analysis further research between LVH & sustained arrhythmias is needed to infer true causality.
Saurav C, Chirag B, et al. Meta-Analysis of Left Ventricular Hypertrophy and Sustained Arrhythmias. The American Journal of Cardiology. Volume 114, Issue 7, Pages 1049-1052 (1 October 2014).
Category: Orthopedics
Keywords: heel, pain, causes (PubMed Search)
Posted: 1/17/2015 by Michael Bond, MD
(Updated: 11/14/2024)
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We often think of Plantar Fascitis as the cause of heel pain but there are a lot of other causes. Some of those include:
Category: Toxicology
Keywords: intraosseous, hydroxocobalamin, cyanide poisoning (PubMed Search)
Posted: 1/15/2015 by Hong Kim, MD
(Updated: 11/14/2024)
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Hydroxocobalamin is an effective cyanide antidote when administered intravenously. Although intraosseous (IO) access is often used in critically ill patients with difficult or delayed IV access, the efficacy of IO administration has not been investigated until recently.
In a recent randomized animal study, acute cyanide toxicity was induced in two groups of swine where 150 mg/kg Hydroxocobalamin was administered via IV vs. IO. The survival rate, reversal of hypotension, and laboratory results were similar between the IV and IO group.
The finding of this study suggest that IO administration of Hydroxocobalamin is as efficacious as IV administration and its administration in acute cyanide toxicity should not be delayed due to lack of IV access when IO access is available.
Bebarta VS, Pitotti RL, Bondreau S and Tanen DA. Intraosseus versus intravenous infusion of hydroxocobalamin for the treatment of acute severe cyanide toxicity in a swine model. Academic Emergency Medicine. 2014; 21 (11): 1203-1211.
Category: Neurology
Keywords: traumatic brain injury, progesterone, neuroprotectant, clinical trials, PROTECT III, SYNAPSE (PubMed Search)
Posted: 1/14/2015 by WanTsu Wendy Chang, MD
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Is progesterone yet another disappointing neuroprotectant?
Traumatic brain injury (TBI) affects more than 1.7 million persons in the U.S. annually. The incidence of TBI is increasing globally, especially in developing countries. Despite improvement in trauma systems and critical care, the morbidity and mortality associated with severe TBI remain high.
Progesterone has been shown in preclinical and phase 2 randomized clinical trials to have pluripotent neuroprotective properties and improve mortality in TBI.
Two multicenter phase 3 trials were recently completed and published in the December 25th issue of the New England Journal of Medicine. However, their results were disappointing.
Both studies used the Glasgow Outcome Scale (GOS) or Extended Glasgow Outcome Scale (GOS-E) at 6 months as their primary outcome. The GOS and GOS-E capture the degree of recovery from brain injury in terms of disability, stratified into levels by death, vegetative state, severe disability, moderate disability, and good recovery.
Progesterone was not found to have any benefit in functional outcome at 6 months.
Both of these studies were well designed and conducted. However, they were based on small effect sizes of the phase 2 trials. In addition, they had very favorable outcome rates in the placebo group, thereby making it hard to demonstrate a benefit by their sample sizes.
There has been a long history of failed neuroprotectant trials likely due to the complex and variable injury mechanisms involved in TBI. The currently available outcome measures are also insensitive to the targeted mechanistic endpoints. More research is needed to understand not only potential therapies but also how to select appropriate patients for these therapies.
Take Home Point: Progesterone does not have any clear benefit in TBI at this time.
Wright DW, Yeatts SD, Silbergleit R, et al. Very early administration of progesterone for acute traumatic brain injury. N Engl J Med. 2014;371(26):2457-2466.
Skolnick BE, Maas AI, Narayan RK, et al. A clinical trial of progesterone for severe traumatic brain injury. N Engl J Med. 2014;371(26):2467-2476.
Category: Critical Care
Keywords: diaphragm weakness, respiratory failure (PubMed Search)
Posted: 1/13/2015 by Feras Khan, MD
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Diaphragm weakness and its significance
There are several ways to monitor diaphragm strength and function
Clinical Relevance
Curr Opin Crit Care. 2015 Feb;21(1):34-41. doi: 10.1097/MCC.0000000000000168.
Monitoring and preventing diaphragm injury.
Category: Visual Diagnosis
Posted: 1/12/2015 by Haney Mallemat, MD
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60 year-old male presents with rhinorrhea, body aches, and dry cough for two days. He recently moved here from Kentucky. What’s the diagnosis (please note that there are several differentials based on CXR)?
Answer Histoplasmosis
Histoplasma capsulatum is the fungus that causes histoplamosis, and is endemic to soil in the “Histo belt” of the U.S. (including all of Arkansas, Kentucky, Missouri, Tennessee, and West Virginia and parts Alabama, Illinois, Indiana, Iowa, Kansas, Louisiana, Maryland, Mississippi, Nebraska, Ohio, Oklahoma, Texas, and Virginia); it is found internationally as well.
Outbreaks have occurred following digging up the ground at construction at sites where this yeast lives in the soil, but spores can also become airborne and inoculate people.
Most cases are asymptomatic, but it is associated with a variety of pulmonary syndromes and can have extrapulmonary findings such as splenic calcifications. Disseminated disease typically occurs in immunocompromised patients
Treatment includes itraconazole for mild to moderate disease and amphotericin for disease that is severe or widespread disease.
Differentials:
- Blastomycosis
- Septic emboli
- Sarcoidosis
- Tuberculosis (milliary)
- Aspergillosis
- Carcinoid lung tumor
- Atypical or viral pneumonias
Category: Cardiology
Posted: 1/12/2015 by Semhar Tewelde, MD
(Updated: 11/14/2024)
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APACHE-HF Scoring System
The Acute Physiology and Chronic Health Evaluation (APACHE) scoring system was established in the 1980's to predict critically ill patient prognosis (APACHE II, III, and IV have been published in last two decades).
The APACHE II scoring system involves combining 3 separate scores (acute physiology score, chronic health score, and age), which can be cumbersome to apply & thus is not often utilized in the emergency department (modified APACHE II doesn't include chronic health score & is less taxing).
No unique scoring system for acute heart failure (AHF) has been analyzed until present; the APACHE-HF score includes 8 criteria: mean arterial pressure (MAP), pulse, sodium, potassium, hematocrit, creatinine, age, and glasgow coma score (GCS).
AHF in-hospital mortality data was analyzed and compared using APACHE II, modified APACHE II, and APACHE- HF scores and the predictive value of the APACHE-HF score was found to be optimal when compared to the others.
Hirotake O, Akihiro S, et al. New scoring system (APACHE-HF) for predicting adverse outcomes in patients with acute heart failure: Evaluation of the APACHE II and Modified APACHE II scoring systems. Journal of Cardiology. Volume 64, Issue 6, Pages 421-510 (December 2014)
Category: Orthopedics
Keywords: Contusion, hematoma (PubMed Search)
Posted: 1/10/2015 by Brian Corwell, MD
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Mechanism: Direct blow to anterior thigh (Football/basketball) or from a ball traveling at a high rate of speed (field hockey/lacrosse).
Exam: focal tenderness and edema. Pain may be severe and worse with active contraction and passive stretch. Hematoma may already be present. Amount of passive knee flexion at 24 hours can be a clue to the severity of the hematoma.
Treatment: Crutches if pain with weight-bearing. Ice. Immobilization in 120 degrees of flexion immediately after the injury for the first 24 hours may be beneficial.
-Bandage entire lower limb. Provide crutches and pain medication. Soft tissue therapy is contraindicated for the first 48 hours and when instituted must be gentle and cause no pain. Risk of re-bleeding is greatest in first 7 to 10 days.
http://fce-study.netdna-ssl.com/2/images/upload-flashcards/75/20/63/5752063_m.jpg
Category: Pediatrics
Posted: 1/10/2015 by Rose Chasm, MD
(Updated: 11/14/2024)
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Andolfatto G, et al. Intranasal ketamine for analgesia in theemergency department: a prospective observational study. Acad Emerg Med. 2013. Oct;20(10):1050-4.
Tsze DS, et al. Intranasal ketamine for procedural sedation in pediatric laceration repair: a preliminary report. Pediatr Emerg Care. 2012. August;28(8);767-70.
Hall D, et al. Intranasal ketamine for procedural sedation. Emerg Med J. 2014;31:789-90.
Category: Toxicology
Keywords: whole bowel irrigation, WBI, GI decontamination (PubMed Search)
Posted: 1/6/2015 by Bryan Hayes, PharmD
(Updated: 1/15/2015)
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Application to Clinical Practice
WBI can facilitate removal of select toxicants from the gastrointestinal tract in some patients, but there is no convincing evidence from clinical studies that it improves the outcome of poisoned patients.
Thanacoody R, et al. Position paper update: Whole bowel irrigation for gastrointestinal decontamination of overdose patients. Clin Toxicol 2015;53(1):5-12. [PMID 25511637]
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Category: International EM
Keywords: Tuberculosis, infectious disease (PubMed Search)
Posted: 1/7/2015 by Jon Mark Hirshon, PhD, MPH, MD
Click here to contact Jon Mark Hirshon, PhD, MPH, MD
Tuberculosis (TB) is a major infectious disease that occurs worldwide.
Fortunately, public health and clinical measures have had some success.
Bottom line:
http://www.who.int/mediacentre/factsheets/fs104/en/
http://www.cdc.gov/tb/topic/treatment/
Category: Critical Care
Posted: 1/6/2015 by Mike Winters, MBA, MD
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"PQRST" - Capnography in Cardiac Arrest
Heradstveit BE, Heltne JK. PQRST - A unique aide-memoire for capnography interpretation during cardiac arrest. Resuscitation 2014; 85:1619-20.
Category: Visual Diagnosis
Posted: 1/5/2015 by Haney Mallemat, MD
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A male patient presents with right lower quadrant pain. The ultrasound is shown at the point of maximal tenderness. The diameter of the structure (image on right) is about 0.94cm. What is this structure and what's the diagnosis?
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Category: Pediatrics
Keywords: intraosseous access, pediatrics (PubMed Search)
Posted: 1/3/2015 by Ashley Strobel, MD
(Updated: 11/14/2024)
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Are you comfortable with Intraosseous Catheter Placement in Children during a code? A pediatric code or child in distress is also distressing to care providers. Your staff may not feel comfortable with IO access in children. Read on to be more comfortable with your options as IO access in children can be difficult, especially the chubby toddlers. The basics for a patient in distress are "IV, O2, Monitor". Access is vital to giving resuscitation medications.
Indications for IO access: Any child in whom IV access cannot readily be obtained, but is necessary.
All IOs are 15G for infusion equal to central vascular access.
Different colors indicate different sizes:
Preferred sites:
Kids-do NOT use the sternum or distal radius
The reference from NEJM has videos to review placement and different tools (manual, EZ IO, and autoinjector).
Category: Pharmacology & Therapeutics
Keywords: headache, migraine, metoclopramide, magnesium (PubMed Search)
Posted: 12/31/2014 by Bryan Hayes, PharmD
(Updated: 1/3/2015)
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Does IV magnesium have a role in the management of acute migraine headache in the ED? A new study says yes. [1]
Intervention
What They Found
Magnesium sulfate was more effective in decreasing pain severity at 20-min (pain scale 5.2 vs. 7.4) and 1-h (2.3 vs. 6.0) and 2-h (1.3 vs. 2.5) intervals after treatment (p < 0.0001) compared to treatment with dexamethasone/metoclopramide.
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Category: International EM
Keywords: Injuries, alcohol, fireworks (PubMed Search)
Posted: 12/31/2014 by Jon Mark Hirshon, PhD, MPH, MD
(Updated: 1/7/2015)
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As you get ready to celebrate the coming of a new year, it is important to be safe while you are having a good time.
Injuries seen during holidays, such as new years, include:
If you are working, be ready to see increased alcohol and injury related visits.
If you are off and plan to celebrate, be sure to identify a designated driver or an alternate means of getting home.
Have a Happy and Safe 2015!