Blood Pressure Management in Severe Preeclampsia

• Severe preeclampsia (preeclampsia + at least one severe complication) accounts for almost 40% of deaths in obstetrical ICU admissions.
• Systolic arterial hypertension is the most important predictor of morbidity in patients with severe preeclampsia.
• First-line agents to reduce blood pressure in severe preeclampsia are nicardipine and labetalol.
• Hydralazine is no longer recommended as first-line therapy.
• Magnesium is used as an anticonvulsant and should not be considered an antihypertensive.

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Question

7 year-old male "jammed" 5th finger while playing basketball with pain and swelling over finger. What's the diagnosis?

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A sports hernia is a painful musculotendinous injury to the medial inguinal floor.

It is the result of repetitive eccentric overload to the abdominal wall stabilizers of the pelvis.

It is common in sports that require sudden changes of direction or intense twisting movements.

Despite the term "hernia" in the title, it is not a true hernia as there is no "herniation" of abdominal contents

http://www.ssorkc.com/wp-content/uploads/2014/09/publagia.gif

Figure description: The upward and oblique pull of the abdominal muscles on the pubis fights against the downward and lateral pull of the adductors on the inferior pubis. This imbalance of forces can lead to injury.

PE: Evaluation of other GU/GYN/other intra-abdominal pathology comes first.

Clinician may note tenderness of the pubic ramus and medial inguinal floor.

Pain is more severe with resisted hip adduction and with resisted sit-up.

Combining these maneuvers (resisted situp while adducting hips) recreates the pathophysiology described above and is a good exam maneuver.

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The New England Journal of Medicine and Lancet both published studies evaluating idarucizumab for reversal of dabigatran. It is a monoclonal antibody fragment that binds dabigatran with high affinity. Dr. Ryan Radecki summarizes the two articles on his EM Lit of Note blog.

Here are a few take home points from these early studies:

1. Both studies were funded by Boehringer Ingelheim, who not suprisingly also markets dabigatran. Skepticism is always welcome when the same company makes the drug and the antidote.
2. The Lancet study was conducted in healthy volunteers, while the NEJM study was conducted in patients needing reversal but lacked a control group.
3. Idarucizumab seems to reverse laboratory markers of anticoagulation from dabigatran rapidly and completely, including dilute thrombin time and ecarin clotting time. Not all institutions have these assays available.
4. The dose that seems to 'work' the best is 5 gm given IV (two-2.5 gm infusions given no more than 15 minutes apart).
5. Median investigator-reported time to cessation of bleeding was 11.4 hours in the NEJM study.
6. 21 of the 90 patients in the NEJM study had 'serious adverse effects' including thrombotic events.
7. The acquisition cost of this medication will most assuredly be high if and when it is FDA-approved in the U.S.

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Cerebrospinal Fluid (CSF) Shunts

• CSF shunts are used to manage hydrocephalus by diverting CSF from either the ventricles within the brain or the subarachnoid space around the spinal cord to another body region. (Figure 1)
• Several types of CSF shunts exist; common types are:
  • Ventriculoperitoneal shunt
  • Ventriculoatrial shunt
  • Ventriculopleural shunt
  • Lumboperitoneal shunt
• A CSF shunt consists of 3 parts:
  • An inflow catheter directly draining CSF.
  • A one-way valve mechanism regulating the amount of CSF drainage.
  • An outflow catheter directing CSF to the drainage site.
• There are 2 types of valve mechanisms:
  • Fixed pressure valves regulate CSF drainage by a predetermined pressure threshold (i.e. low, medium, high).
  • Adjustable pressure valves can be non-invasively adjusted, via specially designed magnetic tools, to set the pressure threshold.
  • Some valves include a reservoir that can be used to test shunt function or to sample CSF for laboratory studies. (Figure 2)
• Shunt-related complications include:
  • Shunt malfunction (disconnection, migration, breaks, obstruction)
  • Shunt infection / ventriculitis / meningitis
  • Over-drainage
• A special consideration for adjustable pressure valves is precaution around magnetic devices.  If a patient is undergoing a MRI, it is recommended for the valve setting to be checked and adjusted afterwards if necessary.

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Attachments

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Question

15 year-old female field hockey player presents with left shoulder pain. Besides fatigue over several weeks, she has no past medical history and there is nothing remarkable on physical exam. What's the diagnosis? 

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Transitioning Diabetic Ketoacidosis (DKA) patients off an insulin infusion can be challenging. If a long-acting insulin, such as glargine or levemir, is not administered at the correct time to provide extended coverage, patients can revert back into DKA.

Pilot Study

A prospective, randomized, controlled pilot study in 40 patients evaluated administration of glargine within 2 hours of insulin infusion initiation compared to waiting until the anion gap (AG) had closed.

What they did

• All patients received IV insulin.
• Experimental: Subcutaneous insulin glargine given within 2 hours of diagnosis.
• Control: Patients subsequently transitioned to long-acting insulin upon closure of AG.

What they found

Mean time to closure of AG, mean hospital LOS, incidents of hypoglycemia, rates of ICU admission, and ICU LOS were all similar between the groups.

Application to Clinical Practice

Although just a pilot study (using a convenience sample), early glargine administration seemed to be absorbed adequately (based on time to AG closure) and was not associated with increased risk of hypoglycemia. If confirmed in a larger study, this technique could help optimize care of DKA patients in the ED by eliminating the often-mismanaged transition step later on.

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As noted in a previous pearl (see 1/7/2015), tuberculosis (TB), caused by Mycobacterium tuberculosis, is the second greatest infectious killer after HIV/AIDS globally. While the incidence and death rate from TB is decreasing, it is still a widespread problem.

• 9 million people fell ill with TB in 2013
• 1.5 million deaths
• Most deaths (95%) occur in low- and middle-income countries
• Among the top 5 causes of death in women aged 15 to 44

Mycobacterium tuberculosis primarily attacks the lungs.  However, it can attack any part of the body such as the kidney, spine, and brain. TB is primarily spread person to person through the air, for example when a person with TB coughs, sneezes, speaks, or sings.

Once a person is infected with TB, the likelihood of developing disease is greater if the person:

• Is HIV infected;
• Has recently acquired TB infection (past 2 years);
• Has other health problems, like diabetes, that impair the immune response;
• Is a substance abuser (alcohol or illegal drugs);
• Was not adequately treated in the past for TB.

Classic symptoms for pulmonary TB include:

• A prolonged (> 3 weeks) bad cough
  • coughing up blood or sputum
• Pain in the chest
• weakness/ fatigue
• weight loss
• anorexia
• chills
• fever
• sweating at night

Other TB symptoms can also include:

• Prolonged headaches and mental status changes (TB meningitis),
• Prolonged back pain/stiffness leading to lower extremity paralysis, or single joint arthritis (skeletal TB)
• Flank pain, frequent urination, scrotal mass or epididymo-orchitis, pelvic inflammatory disease (genitourinary TB)

Bottom line

In the emergency department, maintain a strong clinical awareness for tuberculosis for someone with night sweats, cough, chest pain, and intermittent fever lasting for 3 weeks or longer.  In particular, consider this diagnosis for someone from a low- or middle-income country or if he or she is HIV positive.

Next time: Testing and treatment for TB.

Also see prior pearls on TB: Multidrug Resistant Tuberculosis (MDR TB) (1/21/2015), Tuberculosis (1/7/2015); XDR Tuberculosis (8/14/2013); PPD positive? Good news... (2/6/2013)

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With a new academic year starting, it is important to review some details on central lines

Complications of central lines (TLC-Triple lumen catheter)

• Pneumothorax (more common with subclavian)
• Arterial puncture (more common with femoral)
• Catheter malposition
• Subcutaneous hematoma
• Hemothorax
• Catheter related infection (historically more with femoral)
• Catheter induced thrombosis
• Arrhythmia (usually from guidewire insertion)
• Venous air embolism (avoid with Trendelenburg position)
• Bleeding

Avoiding infections: hand hygiene, chlorhexidine skin antisepsis, maximal barrier precautions, remove unnecessary lines, full gown and glove w/ mask and sterile technique.

Catheter position: 16-18cm for Right sided and 18-20 cm for Left sided. But can vary based on height, neck length, and catheter insertion site. Approximate length based on these factors.

Flow rates: Remember that putting in a central line does not necessarily improve your flow rates in resuscitation

16 G IV: 220 ml/min

Cordis/introducer sheath: 126 ml/min

18 G IV: 105 ml/min

16G distal port TLC: 69 ml/min

Ports (Can vary with type of catheter)

1. Distal exit port (16G)

2. Middle port (18G)

3. Proximal port (18G)

Arterial puncture: hold pressure for 5 mins and evaluate for hematoma formation (harder for subclavian approach)

Arterial cannulation: Has decreased due to ultrasound use but if you do cannulate an arterial site, don’t panic. Don’t remove the line. You can check a blood gas or arterial pulse waveform to confirm placement.  Call vascular surgery for open removal and repair or endovascular repair. You could potentially remove a femoral arterial line and hold pressure but seek vascular advice regarding possible closure devices to use after removal.

Question

25 year-old male falls from 10 feet and lands on his right shoulder, what's the diagnosis?

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Giant Cell Myocarditis

Giant cell myocarditis (GCM) is an infrequent, but often fatal form of acute myocarditis that has been shown to respond to cyclosporine-based immunosuppressive therapy

Even after heart transplantation GCM recurrence in the donor heart has been cited as high as 20% to 25%

Patients are surviving longer without transplantation because of efficacious medical therapy

A multi-institutional prospective data set revealed several novel findings in GCM:

·      Long-term immunosuppression appears capable of lengthening transplantation-free survival ~19 years beyond initial diagnosis

·      Cessation and/or reduction of immunosuppression are associated with GCM recurrence

·      Patients who developed cyclosporine associate renal failure were able to be switched to a sirolimus-based regimen

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Colles fracture

Almost 90% of distal radius fractures

Mechanism: Fall on the outstretched, hyperextended, radially deviated wrist with the forearm in pronation

Often seen in older patients and in those with osteoporosis

Distal radius fracture with dorsal angulation/displacement and/or radial shortening. "Dinner fork deformity"

https://en.wikipedia.org/wiki/Colles'_fracture#/media/File:Colles_fracture.JPG

Smith fracture (aka reverse Colles fracture)

Mechanism: Fall on the outstretched, flexed, radially deviated wrist with the forearm in pronation

Usually younger patients with high energy mechanism

Distal radius fracture with volar angulation or volar displacement. "Garden spade" deformity

Often unstable requiring ORIF

http://www.radiologyassistant.nl/data/bin/w440/a50979780ec887_Smith'-tek.jpg

Radial styloid fracture aka Chauffeur fracture

Fall causing compression of scaphoid against the styloid with wrist in dorsiflexion and ulnar deviation

Often associated with intercarpal ligamentous injuries (i.e., scapholunate dissociation, perilunate dislocation)

Often requires ORIF

http://images.radiopaedia.org/images/611818/cc52cce7bcfd8c905bcc7b5d2b6a65.jpg

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Question

30 year-old patient presents with palpitations. A parasternal long-axis clip is shown below along with the rhythm strip. What's the diagnosis and what drug was given during this clip? 

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Steroid Use in the treatment of Acute Sciatica

Have you used oral steroids in the treatment of your patient with acute sciatica thought to be secondary to a herniated disk.

Well a recent randomizaed, double-blind, placebo-controlled trial from 2008 to 2013 in a large integrated health care system in Northern California enrolled 269 patients to look at whether steroids improved pain or function. The intervention arm (twice as large as placebo arm) received a tapering 15-day course of oral prednisone (5 days each of 60 mg, 40 mg, and 20 mg; total cumulative dose = 600 mg; n = 181).

In the end there were no differences in surgery rates at 52-week follow-up, and the steroid arm had a modest improvement in function but no improvement in pain. There were also more adverse events at 3-week follow-up in the prednisone group than in the placebo group.

Conclusion: Giving steroids for acute sciatica does not appear to improve the patients pain, only has a modest improvement in function, and was associated with more adverse events. Put another way there was minimal benefit and more harm.

You can check out the full article at http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2015.4468

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Sodium valproate (VPA) had been studied and found to be effective in the adult population for migraines, but not in the pediatric population.  This article was a small (12 patient) retrospective study of pediatric migraine patients looking at pain scores before and after VPA administration.  Prior to VPA, patients received NSAIDs, dopamine antagonists, IV fluids and narcotics.  Mean pain reduction prior to VPA was 17%.  After VPA, pain scores were reduced by an additional 36%.

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Recently, there has been a surge in synthetic cannabinoid in the U.S., including the Baltimore area. According to U.S. poison control center data, there has been 229% increase in calls related to SC between January to May of 2015 compared to similar time period in 2014.

The most commonly reported adverse/clinical effects included:

• Agitation: 35.3%
• Tachycardia: 29%
• Drowsiness/lethargy: 26.3%
• Vomiting: 16.4%
• Confusion: 16.4%

End-organ injuries have been also reported in case reports, including AKI, seizure, MI, and CVA.

Synthetic cannabinoid includes a list of chemical compounds that are structurally different compared to THC – the active compound in marijuana. However, they possess full CB1 (cannabinoid) receptor agonism effect, unlike the THC, which is a partial CB1 receptor agonist. 

These chemicals (particularly JWH series) were originally synthesized to study the effect of cannabinoid receptors. Overall, it is difficult to identify the compound and the dose within each packets of SC.

Commonly marketed names include: Spice, K2, K9, herbal highs, Scooby snax, WTF.

Table. Identified synthetic cannabinoids

Management: Majority of the patients with acute SC intoxication mostly requires supportive care, including benzodiazepine for acute agitation. However, ED providers should be mindful of potential end-organ injury. 

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While most infections from parasites are associated with poor communities in low-income countries, there are still some important parasitic infections found in the United States.

The U.S. Centers for Disease Control and Prevention (CDC) has identified 5 parasitic diseases as priorities for public health action based upon:

• Number of infected individuals
• Severity of illness
• Ability to prevent and treat the diseases

These are

• Chagas Disease
  • More than 300,000 people in the U.S. are infected with Trypanosoma cruzi, the parasite that causes Chagas disease
• Cysticercosis
  • At least 1,000 people are hospitalized annually with neurocysticercosis
• Toxocariasis
  • 70 individuals, mostly children are blinded annually from toxocariasis
• Toxoplasmosis
  • More than 60 million individuals carry Toxoplasma gondii, but it usually doesn’t cause symptoms in immunologically competent individuals. 
  • However, it is the 2^nd leading cause of death from foodborne illness and it can cause severe problems during pregnancy and in immunocompromised individuals.
• Trichomoniasis
  • 3% of women in the U.S. are infected with this sexually transmitted parasite
  • 1.1 million people newly infected annually

Bottom line:

Remember to keep your differential broad and maintain awareness of these generally unusual but important infections.

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Renal Resuscitation using Renal Interlobar Artery Doppler (RIAD)

Shocked patient…. check! Adequate volume resuscitation…. check!  Vasopressors.… check! Mean arterial pressure (MAP) > 65 mmHg….. check!  Adequate urine output…. Wait, why isn’t my patient making urine?

As we begin to understand more about shock, hemodynamics, and the importance of perfusion over the usual macrocirculatory goals (MAP > 65), finding ways to assess regional blood flow is critical.  A recent study examined the effect of fluid administration on renal perfusion using renal interlobar artery Doppler (RIAD) to assess the interlobar resistive index (RI).  See how to perform a RIAD here.

They also recorded the fluid challenge’s effect on the traditional hemodynamic measurements of MAP and pulse pressure (PP) then observed the patient’s urine output (as a clinical marker of perfusion).  The authors reported 3 key findings:
 

1. In the hemodynamically impaired patient, a fluid challenge results in reduced intrarenal vasoconstriction (a reduction in the RI).
2. In the hemodynamically impaired patient, changes in RI are more effective than changes in MAP or PP in predicting an increase in urine output after a fluid challenge.
3. Using RI to guide fluid therapy may be limited by small changes and technical limitations.

Bottom Line: The use of ultrasound to determine intrarenal hemodynamics is an interesting strategy to guide renal resuscitation in the shocked patient.  There is mixed data on the use of RIAD, however this study could explain the findings of SEPSISPAM and also addresses the growing concern that traditional hemodynamic goals may be inadequate resuscitation targets.

References

1. Moussa MD, Scolletta S, Fagnoul D, et al. Effects of fluid administration on renal perfusion in critically ill patients. Crit Care. 2015;19(1):250.
2. Asfar P, Meziani F, Hamel JF, et al. High versus low blood-pressure target in patients with septic shock. N Engl J Med. 2014;370(17):1583-93.

For more critical care & resuscitation pearls, follow me on Twitter @JohnGreenwoodMD

Question

Patient presents with headache and papilledema. What's the diagnosis?

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