Case: A 3 year 9 month female presents with fever to 39.4 C and intermittent abdominal pain worsening over 2 days. The patient had been tolerating food and had no change in her bowel habits. Based on the imaging below, what is your diagnosis and treatment?
All benzodiazepines are metabolized by the liver. Some are just metabolized by pathways that are less dependent on global liver function.
The ‘LOT’ drugs are metabolized by conjugation, have no active metabolites, and have minimially affected half-lives even in the setting of liver disease.
L – Lorazepam
O – Oxazepam
T – Temazepam
The rest of the benzodiazepines are primarily metabolized via hepatic CYP-mediated oxidation and may have prolonged duration of effect in patients with marked liver impairment.
For a bit more detail and commentary by Dr. David Juurlink, please read my recent post on the Academic Life in Emergency Medicine blog: http://academiclifeinem.com/all-benzodiazepines-are-metabolized-by-the-liver/
Helicopter EMS (HEMS) has rapidly grown over the past 30 years. HEMS is frequently used to transport trauma patients from the scene of a crash. The question is: for which trauma patients is HEMS most useful?
A recent article published in the Journal of the American Medical Association, based upon data from the National Trauma Data Bank (NTDB), looked at injured patients transported to a trauma center by helicopter versus ground ambulance. It showed that, after controlling for multiple known confounders, more severely injured patients had better outcomes when transported by helicopter than when transported by ground ambulances. Another recent article in the Journal of Trauma and Acute Care Surgery, again based upon the NTDB further showed that HEMS survival benefit seems to limited to individuals with physiologic instability.
Bottom Line:
Transport of severely injured trauma patients by helicopter versus ground from the scene of injury to a trauma center improved patient outcomes and decreased mortality. Transportation of stable, less injured patients by helicopter may actually worsen outcomes.
University of Maryland Section of Global Emergency Health
Author: Jon Mark Hirshon
Acalculous Cholecystitis in the Critically Ill
28 year-old cachectic female presents in respiratory distress and is immediately intubated on arrival to Emergency Department. What's the diagnosis and what are some potential etiologies?
Diagnosis of STEMI in patients with LBBB can be challenging. Guidelines that previously recommended emergent reperfusion for these patients have been reconsidered to avoid inappropriate cath lab activation and fibrinolytic therapy.
The 2013 ACC/AHA STEMI guidelines no longer consider new or presumably new LBBB a STEMI equivalent. This dramatic change may prevent inappropriate therapy for some, but fail to help identify patients with LBBB who are having STEMI's. Delayed reperfusion in this population could be fatal and is estimated to affect 5,000-10,000 patients per year in the US alone.
The Sgarbossa ECG criteria are the most validated tool to aid in the diagnosis of STEMI in the presence of LBBB. A Sgarbossa score of ≥ 3 has high specificity (>98%) and positive predictive value for acute MI and angiography-confirmed coronary occlusion. The following algorithm has been recently proposed to identify the high-risk population in which reperfusion therapy would be denied by the 2013 STEMI guidelines.
Watch this video to review Sgarbossa criteria and the modified Sgarbossa rule.
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Cauda equina syndrome results from compression of multiple lumbar and sacral nerve roots
Causes: Central disc herniation, spinal epidural abscess, malignancy, trauma, hematoma.
Consider this entity in those with back pain and radiculopathy at multiple spinal levels
Urinary retention occurs in >90% of patients
Saddle anesthesia occurs in 75%
Decreased rectal sphincter tone occurs in 60 to 80%
A post void residual volume <100 mL makes this entity very unlikely
When patients with severe allergies to penicillin (urticarial, bronchospasm, anaphylaxis, angioedema) are excluded, the cross reactivity to cephalosporins is very low (approximately 0.1%)
The reaction is related to structures in the side chain, not the cyclical structure as thought in the past.
There are several cephalosporins with IDENTICAL side chains that should not be given to patients with allergies to specific penicillins, namely:
Case Presentation:
A 56y/o man with diabetes presents with fever, cough, and diarrhea x 2 days.
V/S: T:38.7 BP:165/88 P: 105 R:24 O2 sat:91% on room air
CXR: left lower lobe infiltrate.
On further history you learn he has just returned from visiting family in Saudi Arabia 7 days ago. While there, he visited a cousin that was ill.
Clinical Question:
Should this patient be isolated for Middle Eastern Respiratory Syndrome – Corona Virus (MERS-CoV)?
Answer:
Yes, there are 150 cases to date and 64 have died. None confirmed in the US yet but 6 confirmed in Europe.
Patients who should be isolated in an airborne iso room with N95 mask use (similar to TB) are:
Patients with fever + pneumonia/ARDS AND one of the following:
Bottom Line:
In patients with febrile respiratory illness requiring hospitalization and recent travel to the Arabian Peninsula: isolate for MERS-CoV and contact the health department.
University of Maryland Section of Global Emergency Health
Author: Jenny Reifel Saltzberg
Ineffective triggering is the most common type of ventilator dyssynchrony. The differential diagnosis includes:
Auto peep is the most common cause of ineffective triggering and will often occur as a patient cannot create enough inspiratory force to overcome their own intrinsic peep (PEEPi). Patients who are severely tachypnic or those with obstructive lung disease are at high risk for auto peep (not enough time to exhale).
Ineffective triggering can also occur if the patient cannot create enough of a negative inspiratory force to trigger the vent to deliver a positive pressure breath. Prolonged period of mechanical ventilation, over sedation, high cervical spine injuries, or diaphragmatic weakness are common causes.
Lastly, improper trigger sensitivities may make it difficulty for the ventilator to sense when the patient is attempting to take a spontaneous breath.
For an example of a patient with ineffective triggering, check out: http://marylandccproject.org/2013/10/28/vent-problems1/
This week's visual pearl reviews the structures of the heart when being viewed in a parasternal long-axis view. What do the labels correspond to in the clip below (note: "E" and "F" are valves) and do you see any obvious abnormalities?
Secondary Prevention in AMI
Just as aspirin is pivotal in the treatment of acute coronary syndrome, medications such as beta-blocker, statins, and angiotensin-converting enzyme inhibitors have been proven to be essential in secondary prevention of AMI.
Patients after AMI are typically discharged on appropriate secondary prevention medications; however the prescribed doses are often far below the proven efficacy based on clinical trials.
A review of 6,748 patients from 31 hospitals enrolled in 2 U.S. registries (2003 to 2008) illustrated that only 1 in 3 patients were prescribed these medications at goal doses.
Of patients not discharged on goal doses, up-titration during follow-up occurred infrequently ~25%.
Optimal medication dosing and appropriate titration is integral to prevention of further morbidity and mortality.
A recent meta-analysis has called into question whether contrast-induced AKI even occurs after an IV dye load for radiologic imaging. [1] This conclusion is most certainly up for debate.
Irrespective of that conclusion, prevention of contrast-induced nephropathy is still important. Is there any benefit to using N-acetylcysteine over normal saline in the ED? Probably not according to a new study. [2]
Conclusions
How many times have you been frustrated in the peds ED when you have a child with a URI that has a significant night time cough and you feel like you have nothing to offer them for symptom control? The parent is frustrated because the child is not sleeping which means they are not sleeping and they are looking at you for help. We all know that OTC cough and cold medications are not helpful and may be harmful in children <2 yrs old and should be used with caution in children <6 yrs old. So what can you do? You can recommend a course of HONEY at night. Of course this does not apply to children < 1 yr who are at increased risk of botulism. A recent double-blind placebo-controlled trial published in Pediatrics in 2012 demonstrated reduced night time cough and subjective improved sleep quality in children age 1-5 who were given honey compared to placebo. This study supports previous less rigorous publications that found honey was an effective remedy on cough in children. Mechanism for honey's beneficial effect on cough is unknown but possibly related to close anatomic relationship between sensory nerve fibers that initiate cough and gustatory nerve fibers that taste sweetness. Of note, a recently published survey in Pediatric Emergency Care revealed that 2/3 of parents were unaware of the FDA guidelines regarding OTC cough and cold remedies in children! After you recommend HONEY for night time cough, take an extra minute and educate your parents about the potential dangers of cough and cold medicines in small children!
You have a treat bag full of candy, which one can cause hypertension, hyopkalemia, metabolic alkalosis, rhabdomyolysis, low renin activity, thrombocytopenia and hypoaldosteronism. (scroll down for answer)
Licorice syrup or licorice extract contains glycyrrhizic acid which has a mineralcorticoid-like effect and can cause of all of the effects. Don't worry, Twizzlers and other usual licorice candies do not have true licorice extract in them. It is found in herbal remedies and some "natural" candies and licorice flavored cigars. Don't pick the licorice !
Case Presentation: 28 year old woman from South Africa presents with 5 days of body weakness, nausea, vomiting and cough. BP 86/38, HR 142, RR 36, Temp 101.4 (oral) Sats 96% on RA. PMH: HIV+ last CD4=33, on HAART, history of pulmonary TB which was treated 2 years ago.
Clinical Question: The CT scanner, Xray and labs are down. What work-up can you do to best manage this patient?
Answer: The FASH Exam (Focused Assessment with Sonography for TB-HIV)
Technique: 6 probe positions--Similar to the FAST exam but with additional evaluation of the liver, the aorta, the spleen, as well as evaluation for pleural effusions over the diaphragm.
Evaluate for extrapulmonary TB (EPTB):
-Pericardial/Pleural effusion and ascites
-Periportal/para-aortic lymph nodes
-Focal liver and spleen lesions
(Go to http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554543/ to view images of probe position.)
Bottom Line: The FASH exam can be taught to physicians with limited to no ultrasound experience. If there is concern for EPTB in an undifferentiated hypotensive patient, the FASH exam can performed in the emergency setting and treatment can be started.
University of Maryland Section of Global Emergency Health
Author: Laura Diegelmann, MD RDMS
The pregnant patient normally has increased cardiac output and minute ventilation by the third trimester. Despite this increase, however, these patients have little cardiopulmonary reserve should they become critically-ill.
Remember the mnemonic T.O.L.D.D. for simple tips that should be done for the pregnant patient who presents critically-ill or with the potential for critical illness:
15 year-old right-hand dominant male received a direct blow to the right arm with a hockey stick. What’s the diagnosis?
First-degree atrioventricular (AV) block is defined as an abnormally prolonged PR-interval >200ms. Although traditionally considered to be a benign clinical entity, not all first degree AV blocks are treated the same.
Markedly prolonged PR-intervals (PR >300ms) can cause symptoms and hemodynamic compromise due to inadequate timing of atrial and ventricular contractions. Consider the following ECG from a 32 YOF with intermittent episodes of syncope and dizziness…
There is marked first degree AV block (PR=434 ms). When the PR-interval gets too long, AV dyssynchrony compromises ventricular filling and decreases cardiac output, similar to the so-called pacemaker syndrome.
Current ACC/AHA guidelines state that permanent pacemaker implantation is reasonable for marked first degree AV block with hemodynamic compromise or symptoms similar to those of pacemaker syndrome. (Class IIa, Level of Evidence B). The guidelines caution that pacemakers are not indicated in asymptomatic patients with isolated first degree AV block.
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Lateral hip pain
Findings of weakness and/or pain while testing hip abduction may point to gluteus medius muscle dysfunction with associated with greater trochanteric pain syndrome.
The Trendelenburg test may help. The patient stands on the affected leg. A negative test result occurs when the pelvis rises on the opposite side. A positive test result occurs when the pelvis on the opposite side drops and indicates a weak or painful gluteus medius muscle.
http://www.youtube.com/watch?v=TY-G4ErruUA
