Department Blog

Posted 12/23/2022 by Eileen O'Brien

High-dose nitroglycerin infusion in the ED

Ashley Martinelli, PharmD, UMMC Clinical Pharmacy Specialist, and Amal Mattu, MD, Professor and Vice Chair of the Department of Emergency Medicine, are among the authors of "High-dose nitroglycerin infusion description of safety and efficacy in sympathetic crashing acute pulmonary edema: The HI-DOSE SCAPE study," Am J Emerg Med. 2023 Jan;63:74-78. doi: 10.1016/j.ajem.2022.10.018. Epub 2022 Oct 18. Coauthors were Brandon Houseman and Wesley Oliver of the UMMC Department of Pharmacy and Sandeep Devabhakthuni of the School of Pharmacy at UMB. 
This report is the largest study to examine the infusion of ≥100 mcg/min of nitroglycerin as a strategy for the management of sympathetic crashing acute pulmonary edema (SCAPE). It concludes that infusion may be a safe alternative to intermittent bolus of high-dose nitroglycerin.