Wendy Chang, MD, collaborated with investigators from the Departments of Neurology, Anesthesiology, and Surgery in an analysis of clinical information from patients enrolled in the Oximetry and Noninvasive Predictors of Intervention Need after Trauma (ONPOINT) study. They concluded that continuous vital sign variability and waveform analysis of the electrocardiogram or photoplethysmogram within the first hour after resuscitation constitutes a noninvasive marker of neurologic decline after traumatic brain injury.
Their work was published as the following article:
Melinosky C, Yang S, Hu P, Li H, Miller CHT, Khan I, Mackenzie C, Chang WT, Parikh G, Stein D, Badjatia N. Continuous vital sign analysis to predict secondary neurological decline after traumatic brain injury. Frontiers in Neurology 2018 Sep 25;9:761.