The answer appears to be ... it depends.
Early Oseltamivir Treatment in Influenza in Children1-3 Years of Age: A Randomized Controlled Trial
A study in 2010 out of Finland by Heinonen, et al showed that if given in the first 12 hours of symptom onset to otherwise healthy pediatric patients between the age of 1-3 years:
- decrease incidence of acute otitis media by 85%
- no difference if given within 24 hours
Among children with influenza A, oseltamivir started within 24 hours of symptom onset
- shortened medium time to resolution of illness by 3.5 days (3.0 versus 6.5) in all children
- shortened median time to resolution of illness by 4.0 days in UNvaccinated children
- Reduced parental work absenteeism by 3 days
* no differences were seen in children with influenza B *
Limitations***
- Single Center study in Finland
- The authors received support from the drug manufacturer
- The sample size of children with confirmed influenza cases with small (influenza A: 79, influenza B: 19)
Takeaway:
If you have a patient between the age of 1-3 years with very early symptoms concerning for flu, a positive rapid influenza A test could allow you to cut her symptoms by 3 days, prevent complications, and allow parents to go back to work sooner.
Patients with severe salicylate poisoning may require endotracheal intubation due to fatigue from hyperventilation or mental status change.
A previously published study (Stolbach et al. 2008) showed that mechanical ventilation increases the risk of acidemia and clinical deterioration.
A small retrospective study investigated the impact of hemodialysis (HD) in intubated patients with salicylate poisoning.
Findings:
53 cases with overall survival rate of 73.2%
In patients with salicylate level > 50 mg/dL
If salicylate level > 80 mg/dL
Bottom Line:
There is moratality benefit of HD in intubated salicylate-poisoned patient.
Improving Resuscitation Performance
PCL injuries can sometimes have involvement of the posterolateral corner (PLC)
The dial test can be used to diagnose posterior lateral instability and help differentiate it from isolated PCL injuries
The dial test involves comparing the amount of external rotation of the lower leg at the knee while the knees are in 30° and in 90° of knee flexion.
https://www.youtube.com/watch?v=rnk62Y-nDSQ
An isolated injury to the posterolateral corner will result in more than 10° of external rotation in the injured knee that is present at 30° but not at 90° of knee flexion.
http://www.kneejointsurgery.com/wp-content/uploads/2015/06/DIAL-TEST.jpg
http://www.kneejointsurgery.com/wp-content/uploads/2015/06/DIAL-TEST-90.jpg
Ventricular shunt (VP) malfunction can be severe and life-threatening and evaluation has typically included a dry CT brain and a shunt series which includes multiple x-rays of the skull, neck, chest and abdomen. The goal of this study was to decrease the amount of radiation used in the evaluation of these patients since these patients will likely present many times over their lifetime. Several institutions have more towards a rapid cranial MRI, however, this modality may not be readily available.
This multidisciplinary team decreased the CT scan radiation dose from 250mA (the reference mA in the pediatric protocol at this institution) to 150 mA which allows for a balance between reducing radiation exposure and adequate visualization of the ventricular system. They also added single view chest and abdominal x-rays.
The authors found that after implementing this new protocol, there was a reduction in CT radiation doses and number of x-rays ordered with no change in the return rate.
Vaginal douching is a common and potentially dangerous practice. Women engage in this practice predominately for personal hygiene reasons but also with the false belief it will prevent or treat infections and for contraception. Numerous public health agencies and medical societies discourage douching as it has been associated with many adverse outcomes including pelvic inflammatory disease, bacterial vaginosis, cervical cancer, low birth weight, preterm birth, human immunodeficiency virus transmission, sexually transmitted diseases, ectopic pregnancy, recurrent vulvovaginal candidiasis, and infertility.
An increasing fad is the use of intravaginal detox products. Claiming to enhance female health by removing toxins, these mesh cloth-covered balls containing herbs such as mothersworth, osthol, angelica, borneol, and rhizoma, not FDA-approved, are inserted into the vagina for 3 days. Clinical experience demonstrates these products decompose into numerous pieces which become scattered retained intravaginal foreign bodies, cause mucosal irritation, and thereotically could serve as a nidus for serious infections.
When surveyed, half of general medicine patients interviewed stated that they would prefer to have a loved one present if they were to develop cardiac arrest and require CPR. So far, studies have demonstrated that…
Allowing family presence during CPR is associated with the following benefits to family members:
And is NOT associated with a difference in:
Take Home Points:
Hydrogen peroxide (H2O2) is a common household liquid that is used for wound irrigation/antiseptic and cosmetic purposes. The concentration of household product is 3% to 5% and is considered to be relatively safe except in large volume ingestion.
High-concentration H2O2 (>10%) is commercially available as “food grade” (35%) that is diluted for household use or for alternative medicine therapy (i.e. hyperoxygenation).
Ingestion of high-concentration of H2O2 can result in caustic injury as well as ischemic injury from gas embolism.
Ingestion of 1 mL of 3% H2O2 produces 10 mL of O2 gas while 1 mL of 35% H2O2 produces 115 mL of O2 gas.
Common symptoms/findings of H2O2 ingestions includes:
A retrospective review of >10% H2O2 ingestion from National Poison Data System showed:
Management
50 YOF with acute onset of worst headache of life associated with nausea and vomiting. Patient is somnolent, will rouse to noxious stimuli and complains of a headache as well as decreased vision.
Idiopathic osteonecrosis of the femoral head
Children as young as 2 or as old as 12 but generally 4 to 8 (worse in older children)
Fare better than adults with osteonecrosis of femoral head
1 in 10,000
4-5x more common in males, much less common ini African Americans
Unilateral femoral head involvement 90% of the time (Bilateral 10% of the time)
Long term consequences are deformity and arthritis
Typical presentation: Subacute limping for weeks (Painless)
As activity worsens limp, it is maximal at the end of the day (Intermittent)
As in adults with hip pathology, IF pain is reported, it is located at the upper anterior thigh and groin
On examination, look for restriction in range of motion of the hip (compare with contralateral side)
May only present with mild to moderate decreased range of motion of the hip
30 versus 60 degrees for example
ABduct both legs with pelvis in neutral OR Place one hand on contralateral pelvis and ABduct affected leg with other hand.
Cholera is an acute diarrheal disease that can kill within hours if left untreated.
Rising cholera, diarrhea and malnutrition is a deadly combination in war torn countries, such as Yemen, South Sudan, Somalia and Sudan, especially for children.
Yemen currently has the worst outbreak globally, with over 260,000 suspected cases and over 1,600 deaths. In Yemen:
o Half the suspected cases are children
o A quarter of the deaths are among children
Bottom Line:
Cholera remains a major cause of morbidity and mortality globally, especially in areas of conflict.
When you are working up an elderly patient for trauma look for patterns such as circumferential bruising on the wrists that have the pattern of fingers the same way you would look at the injuries of a child. Remember that the person who is sitting next to them is frequently the person that is abusing them. Therefore, it is important to interview the patient alone.
When you look up dosing for levofloxacin for community acquired pneumonia (CAP), you will find that both of the following options are approved:
This is based on a multicenter, randomized, double-blind, active treatment trial comparing these two regimens in CAP (mild to severe). This non-inferiority trial shows that the 750 mg dose of levofloxacin for 5 days is "at least as effective and well tolerated" as the 500 mg dose of levofloxacin for 10 days.
So why should you choose the 750 mg daily x 5 day regimen?
As alway with levofloxacin, don't forget to renally dose adjust subsequent doses when writting a script or scheduled inpatient order for patients with reduced creatinine clearance!
Black widow spiders belong to the genus Latro dectus which include 31 species of widow spiders found throughout world. Approximately 1500-2500 black widow bites are reported to American poison control centers annually. A black widow can be identified by their hourglass pattern (red or orange) on the ventral aspect of their shiny globular abdomen. Fortunately, envenomation is rare but when it does occur it causes severe pain, muscle cramping, abdominal (may mimic acute abdomen) often refractory to traditional analgesics and antivenom (Antivenin Latrodectus mactans) is available and effective . Alpha-latrotoxin is the potent toxin causing presynaptic cation channels to open (calcium) and release of neurotransmitters such acetycholine. The neurological signs and symptoms caused by predominantly autonomic and include tachycardia and hypertension. The antivenom is equine based and infused over 20-30 minutes with pain relief in 20 minutes.
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Ventilation During Cardiopulmonary Resuscitation
Adhesive Capsulitis aka Frozen Shoulder
Spontaneous gradual onset stiffness and pain of the Glenohumeral joint
Shoulder capsule becomes thickened and contracted
Often affects patients between 40 and 60 years old
Left> Right shoulder
Women> men
Association with diabetes and thyroid disease
3 clinical stages
1) Pain – gradual onset, diffuse, severe, disabling, often worse at night
2) Stiffness – decreased ROM, affects ADLs, improved pain
3) Thawing – gradual return of motion
Physical examination: Painful and decreased ROM. Evaluate active and passive movement, external rotation and ABduction of the shoulder most affected
Surgical or post traumatic shoulder stiffness usually resolves within 12 months.
Adhesive capsulitis is generally self-limiting lasting an average of 18-36 months.
DDX: Chronic locked posterior shoulder dislocation (VERY IMPORTANT), tumor.
Treatment: NSAIDs, Physical therapy, Intra articular steroids
If this fails, manipulation under anesthesia and/or arthroscopic surgical release
Every year in the U.S., preventable poisonings in children result in more than 60,000 ED visits and around 1 million calls to poison centers. Calls relating specifically to pet medication exposure and children have been on the rise.
A recent study in Pediatrics was the first was kind to characterize the epidemiology of such exposures.
This study is a call to arms for an increased effort on the part of public health officials, pharmacists, veterinarians, and physicians to improve patient education to prevent these exposures from occurring.
Summary of major findings:
Most commonly Implicated exposures:
Key contributors to exposure risk:
Take home point: Make sure your pet's medications are appropriately stored for safety!
