UMEM Educational Pearls - Misc

Attitudes, Behavior, and Comfort of Emergency Medicine Residents in Caring for LGBT Patients: What Do We Know?

Background

This paper was written by some of the thought leaders in the Diversity, Equity and Inclusion realm in Emergency Medicine. Undergraduate medical education has minimal formal hours dedicated to LGBTQ+ health, and EM residency has even less. The authors wanted to assess EM resident comfort in caring for patients who identify as part of the LGBTQ+ community

Methodology

An anonymous service was sent out to CORD and was then disseminated to the residents of the 167 ACGME accredited EM residencies. It was a 24-question survey based on a similar one given to medical students. Overall, a total of 319 residents responded to the survey, with the vast majority identifying as heterosexual and cisgender

Results

The results seem at first to be contradictory. A majority of respondents (63.5%) were either comfortable or very comfortable in addressing the needs of LBGT patients. But when asked about specific behaviors related to providing care, there was more to the story. Only 17.3% of respondents always asked about sexual partner gender, 4.7% always asked about sexual orientation for an abdominal or genital complaint.

Perhaps more disturbing, the survey found that 10% of respondents had observed attending physicians make discriminatory or inappropriate comments about LGBT patients or staff, 2% of respondents were uncomfortable working alongside LGBT physicians, and 6% of respondents disagreed with the statement that LGBT patients deserve the same level of quality care as other patients.

Discussion

This study was published in 2019. Despite some amazing advancement in the LGBT community, we obviously still have a long way to go. This study shows the need for more formalized and routine education regarding LGBT population health issues at both the undergraduate and graduate medical education levels. It also demonstrates that LGBT physicians still experience discrimination in the workplace, even within our specialty. Be kind, be compassionate, be understanding.

 

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Title: Mammalian meat allergy (alpha-gal syndrome) following tick bites

Author: Dan Gingold, MD, MPH

Development of IgE antibodies to the oligosaccharide galactose-alpha-1-3-galactose (alpha-gal) appears to be responsible for an acquired allergy to non-primate mammalian meat (i.e., beef and pork) and derived productsAntigen in the salivary apparatus of certain ticks (gross!!) can sensitize an IgE-mediated response to alpha-gal which is present in mammalian meat. 

 
Symptoms are similar to other IgE-mediated hypersensitivity reactions, and can cause a delayed-onset reaction with hives, GI upset, or anaphylaxis after ingestion of red meat. Treatment with standard anti-histamines and epinephrine is effectiveIndividuals with no prior history of meat sensitivity can develop the syndrome at any age, often after exposure to the outdoors in tick-endemic areasSkin and blood allergy testing can confirm the diagnosis. Symptoms can persist for years, but can recede over time if not exposed to further tick bites.

 
In the US, the primary tick responsible is Lone Star Tick (Amblyomma americanum), found primarily in the Eastern, Southeastern, and Midwestern US. Other tick species in Europe, Australia, and Asia have been found to induce the syndrome as well. Interestingly, there is a cross-reactivity with the monoclonal antibody Cetuximab (used to treat colorectal and head and neck cancers), an allergic reaction to which can also induce similar alpha-gal meat sensitivity.

Having first been described in 2009, the syndrome often goes unrecognized; increased physician awareness can inform the evaluation, diagnosis, and education of patients presenting to the ED with undifferentiated allergic reaction.

 
 

 

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Category: Misc

Title: CT Radiation doses

Keywords: CT, head, radiation (PubMed Search)

Posted: 4/13/2019 by Brian Corwell, MD
Click here to contact Brian Corwell, MD

 
  • A recent retrospective study examined CT radiation doses in different types of facilities

 

  • Mean patient age: 12 years
  • Authors reviewed radiation doses for nearly 240,000 CT scans in over 500 facilities
  •  
  • The facilities were categorized into 4 groups: 

 

  • 1) academic pediatric,
  • 2) non-academic pediatric,
  • 3) academic adult, 
  • 4) non-academic adult

 

Most (65%) scans were performed at nonacademic adult centers

 

  • Radiation doses were significantly higher at adult facilities vs. pediatric facilities
  • Also, radiation doses were higher at non-academic vs. academic facilities
  • For example, the largest children received twice the radiation dose for abdomen-pelvis CT scans performed at nonacademic adult facilities compared with academic pediatric facilities
    • 11.9 mGy vs. 5.8 mGy
  • Academic pediatric facilities use lower radiation doses than do nonacademic pediatric or adult facilities for all head CT examinations and for the majority of chest and abdomen-pelvis

 

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Category: Misc

Title: Acute Pain Management in Dental Pain

Keywords: dental pain, ibuprofen, acetaminophen (PubMed Search)

Posted: 4/6/2018 by Michael Bond, MD (Emailed: 4/7/2018)
Click here to contact Michael Bond, MD

Takeaways

Bottom Line:
 
A recent review in the Journal of the American Dental Association found that Ibuprofen 400mg plus acetaminophen 1000mg was the best regimen for the relief of postoperative dental pain when compared to any opioid-containing regimen.

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Category: Misc

Title: Non-Musculoskeletal Causes of Neck Pain

Keywords: Neck pain (PubMed Search)

Posted: 7/16/2016 by Michael Bond, MD (Updated: 8/11/2022)
Click here to contact Michael Bond, MD

Non-Musculoskeletal Causes of Neck Pain

Neck pain is a common complaint of people presenting to the ED. Most of the cases will be musculoskeleteal in origin and will respond to conservative therapy with NSAIDs or acetominophen. However, other non-musculoskeletal causes of pain could be lurky behind this benign complaint.

Don't forget to consider:

  1. Early mengingitis (84% of patients with meningitis will complain of neck stiffness)
  2. Myocardial infarction/angina. Women are known to have atypical symptoms and might just have dull pain in their neck. Be sure to ask about whether exertion increases the pain.
  3. Epidural Abscess- fever and neuro symptoms are often missing early on. Make sure to ask about risk factors for spinal epidural abscess.
  4. Vertebral Artery Discection - most common identifiable cause of stroke in your people.  <50% are associated with trauma and <8% of patients have connective tissue disorder. Patients are at increased risk if they have had
    1. Cervical trauma (remember seen in < 50% of cases)
    2. Recent infection
    3. Hypertension
    4. h/o migraines

 


Category: Misc

Title: Diverticulitis

Keywords: Diverticulitis, antibiotics. (PubMed Search)

Posted: 1/30/2016 by Michael Bond, MD (Updated: 1/31/2016)
Click here to contact Michael Bond, MD

Diverticulitis

It seems like the standard treatment course for patients with suspected diverticulitis in the ED is to obtain a CT of the Abdomen and pelvis and then to start antibiotics. A CT scan is really only needed if you suspect that they have an abscess, micro perforation, are not responding to conventional treatment, or you suspect an alternative diagnosis.

However, what should the conventional treatment be? Several recent studies from Sweden, Iceland and the Netherlands have shown that patients treated with antibiotics did not fair any better then patients who were just observed. There was no difference in time to resolution of symptoms, complications, recurrence rate, or duration of hospitalization.  

Several national societies (Dutch, Danish, German, and Italian) now recommend withholding antibiotics in patients free of risk factors who have uncomplicated disease, but these patients will need close follow up.

TAKE HOME POINT: Patients with diverticulitis can be treated supportively and probably do not require antibiotics unless you suspect they have complicated disease or are immunosuppressed.

 

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Category: Misc

Title: New UMEM Pearls App!

Keywords: app pearls apple google (PubMed Search)

Posted: 10/7/2014 by Kevin Hamilton
Click here to contact Kevin Hamilton

We are proud to announce the release of our new UMEM Pearls App, now available in the Apple App Store and the Google Play Marketplace! You will now be able to pull down pearl content for offline viewing, in addition to having all of the pearls in searchable format available on your mobile devices.

Click either of the following links on your mobile device to download your Pearls App today!

Get it on Google Play!

 

Get it on Apple App Store!


Category: Misc

Title: Drowning

Keywords: Drowning, rescue (PubMed Search)

Posted: 5/24/2014 by Brian Corwell, MD (Updated: 8/11/2022)
Click here to contact Brian Corwell, MD

Happy Memorial Day! With all the recent attention in the news about swimming and drowning I thought I would share this article

 

The Instinctive Drowning Response—so named by Francesco A. Pia, Ph.D., is what people do to avoid actual or perceived suffocation in the water. And it does not look like most people expect. There is very little splashing, no waving, and no yelling or calls for help of any kind. To get an idea of just how quiet and undramatic from the surface drowning can be, consider this: It is the No. 2 cause of accidental death in children, ages 15 and under (just behind vehicle accidents)—of the approximately 750 children who will drown next year, about 375 of them will do so within 25 yards of a parent or other adult. In some of those drownings, the adult will actually watch the child do it, having no idea it is happening.* Drowning does not look like drowning—Dr. Pia, in an article in the Coast Guard’s On Scenemagazine, described the Instinctive Drowning Response like this:

  1. “Except in rare circumstances, drowning people are physiologically unable to call out for help. The respiratory system was designed for breathing. Speech is the secondary or overlaid function. Breathing must be fulfilled before speech occurs.
  2. Drowning people’s mouths alternately sink below and reappear above the surface of the water. The mouths of drowning people are not above the surface of the water long enough for them to exhale, inhale, and call out for help. When the drowning people’s mouths are above the surface, they exhale and inhale quickly as their mouths start to sink below the surface of the water.
  3. Drowning people cannot wave for help. Nature instinctively forces them to extend their arms laterally and press down on the water’s surface. Pressing down on the surface of the water permits drowning people to leverage their bodies so they can lift their mouths out of the water to breathe.
  4. Throughout the Instinctive Drowning Response, drowning people cannot voluntarily control their arm movements. Physiologically, drowning people who are struggling on the surface of the water cannot stop drowning and perform voluntary movements such as waving for help, moving toward a rescuer, or reaching out for a piece of rescue equipment.
  5. From beginning to end of the Instinctive Drowning Response people’s bodies remain upright in the water, with no evidence of a supporting kick. Unless rescued by a trained lifeguard, these drowning people can only struggle on the surface of the water from 20 to 60 seconds before submersion occurs.”

This doesn’t mean that a person that is yelling for help and thrashing isn’t in real trouble—they are experiencing aquatic distress. Not always present before the Instinctive Drowning Response, aquatic distress doesn’t last long—but unlike true drowning, these victims can still assist in their own rescue. They can grab lifelines, throw rings, etc.

Look for these other signs of drowning when persons are in the water:

  • Head low in the water, mouth at water level
  • Head tilted back with mouth open
  • Eyes glassy and empty, unable to focus
  • Eyes closed
  • Hair over forehead or eyes
  • Not using legs—vertical
  • Hyperventilating or gasping
  • Trying to swim in a particular direction but not making headway
  • Trying to roll over on the back
  • Appear to be climbing an invisible ladder

So if a crew member falls overboard and everything looks OK—don’t be too sure. Sometimes the most common indication that someone is drowning is that they don’t look like they’re drowning. They may just look like they are treading water and looking up at the deck. One way to be sure? Ask them, “Are you all right?” If they can answer at all—they probably are. If they return a blank stare, you may have less than 30 seconds to get to them. And parents—children playing in the water make noise. When they get quiet, you get to them and find out why.

 

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Category: Misc

Title: Cause of Post-Operative Fever

Keywords: Postoperative, fever, cause (PubMed Search)

Posted: 1/18/2014 by Michael Bond, MD (Updated: 8/11/2022)
Click here to contact Michael Bond, MD

Post Operative Fever is extremely common, and with the increase in same day surgery this is a common complaint presenting to the ED.  The mnemonic "5Ws" are often taught to remember the causes. They are:

  • Wind - Pneumonia, aspiration, pulmonary embolism, and atelectasis
  • Water - urinary tract infection
  • Walking - Deep Venous Thrombosis or pulmonary embolism
  • Wound - surgical wound infection
  • Wonder drugs - Drug fever, or infection due to indwelling lines, or a reaction to blood products

Though many surgical textbooks report that atelectasis is the most common cause of early post-operative fever,  some even claiming that it is responsible for over 90% of febrile episodes in the first 48 hours after surgery; a recent review in CHEST (reference below) showed that there is no evidence to support this. We often see atelectasis in medical patients too, and few if any of them have fever.  The CHEST review found that there was no clear evidence that atelectasis causes fever at all.

Pearl:  Temperature >38.9C should raise concern for a true infection, where lower temperatures can be due to pulmonary embolism, DVT, drug fever, etc….
 

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"Frozen in January, Amputate in June"  - By Kinjal Sethuraman and Doug Sward
 
Frostbite can lead to major tissue damage even if initial presentation does not look so severe. Treatment is NOT the same as for burns. 

Treatment of Major Frostbite:
1.  Rapid rewarming ASAP of affected area in 40 Celsius degree water until area is thawed (pink and pliable) Logistics are difficult because you have to maintain a constant water temperature- but only if you can maintain same degree of warmth.  Rewarming and refreezing will lead to inevitable tissue death.
2. Wound care, Aloe Vera, ASA 
3.  DELAY surgery except in cases of sepsis or compartment syndrome.
 
CUTTING EDGE:
  • If less than 24 hours since injury, consider diagnostic angiography and  intra-arterial TPA, and heparin infusion, Prostacyclin infusion.
  • Angiography and Bone Scan can be used to prognosticate clinical course.
  • Consider Hyperbaric Oxygen Therapy for moderate to severe frostbite- multiple case reports of significant improvement with HBOT even if delayed by several days. 
 
Treatment of  Minor Frostbite:
1. Rewarm area
2. Ibuprofen
3. Aloe Vera and dressing changes
 
Reference attached from Wilderness Medical Society Practice Guidelines for the Prevention and Treatment of Frostbite  http://www.ncbi.nlm.nih.gov/pubmed/21664561

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Lactate levels help to confirm septic arthritis but what about bacterial meningitis.  As reported in the daily electronic ACEP newsletter a small study of 45 patients showed that all patients with a confirmed diagnosis of bacterial meningitis had a CSF lactate level > 3.5 mmol/L.  Therefore, it might be true that viral meningitis will only have  CSF lactate levels < 3.5 mmol/L. 

With only 45 patients, this finding is clearly not ready for Prime Time but consider adding it to your next CSF study so more data can be collected on the utility of this test.

The story as seen in ACEP eNews on September 14th, 2012 is:

CSF Levels Of Lactate May Be A Marker Of Viral Versus Bacterial Meningitis.

MedPage Today (9/14, Gever) reports, "Cerebrospinal fluid (CSF) levels of lactate were a perfect marker of viral versus bacterial meningitis in a small study, a researcher reported" at the Interscience Conference on Antimicrobial Agents and Chemotherapy. Researchers found that, "among 45 adults in whom the etiology of meningitis was microbiologically confirmed, all those with CSF lactate levels above 3.5 mmol/L had the bacterial form, whereas every patient with lower levels had viral meningitis."


Category: Misc

Title: Jet lag in Athletes (and the rest of us) Part 2

Keywords: jet lag, sleep, athletic performance (PubMed Search)

Posted: 8/11/2012 by Brian Corwell, MD
Click here to contact Brian Corwell, MD

Apologies for the long pearl, I did not want to split this into 3 parts)

Disruptions in sleep and circadian rhythms (from travel across time zones and jet lag) are known to alter cognitive functions. Mood and complex mental performance tasks deteriorate faster than do simpler mental performance tasks.

An athlete’s circadian rhythms are believed to be optimal for performance in the early evening (reaction time to light and sound in the fastest). Interestingly, the evening is the time of day when most world records have been broken. However, activities that require fine motor control and accuracy (hand steadiness and balance) are best in the morning.

In the normal population, travel effects are seen in inattention and an increase in errors and injuries in the workplace.

Athletes who perform in international competitions immediately after time zone transitions demonstrate a decline in performance involving complex mental activities, with an associated feeling of lethargy and a general loss of motivation.

British Olympic athletes demonstrated a decrease in leg and back strength in addition to reaction time when traveling westward across 4 time zones. In the NFL, west coast teams consistently beat east coast teams in evening games.

Of course, this type of outcome data is multifactorial and travel effects likely are only one of many complex factors.

Treatment:

Full adaptation to the new time zone is NOT recommended for short trips (1 – 2 days), only for longer stays (> 3 days).

Nonpharmacologic: 

Preadaptation and bright light therapy: Remember that exposure to light is the primary cue for circadian rhythms. Bright light exposure in the mornings (after eastward travel) will advance the body clock, while exposure in the evenings (after westward travel) will delay it (Level B).

Shifting the sleep schedule 1 - 2 hours towards the destination time zone in the days preceding departure may shorten the duration of jet lag (Level B).

Strategic napping: Napping in the new time zone during typical sleep times in the destination time zone will delay adaptation. Power naps (20 minutes) may be helpful in decreasing daytime sleepiness in those with jet lag (Level B). The best time to nap (in flight or post flight) is nighttime in the destination time zone (Level B).

Pharmacologic:

Melatonin: Cochrane review concludes that it is safe and effective in both treating and preventing jet lag. It is recommended for adults traveling across 5 or more times zones; and may be effective for travel across 2 to 4 time zones. Take melatonin in the morning when traveling westward, and at the local bedtime when traveling eastward (Level B). Doses of 0.5 to 5mg were similarly effective. Melatonin taken in the evening and at higher doses are effective at inducing sleep (Level A).

Sleep aids:  Hypnotic sleep aids reliably induce insomnia secondary to jet lag. Benzodiazepines improve sleep quality but may cause a “hangover” effect the next day, possibly impairing performance.

Ambien (zolpidem) and Lunesta (zopiclone) can be effective while limiting the hangover effect especially in those who have previosly tolerated the medication (Level A). Zolpidem may be more effective than melatonin and placebo at countering jet lag symptoms. Note: the use of both medicines together was not more effective than zolpidem alone but did cause daytime somnolence.

Stimulants: Care should be used in the athlete as most of these medications are banned in competition. There is a potential off label use for Provigil (modafinil) for improving daytime sleepiness associated with jet lag (currently approved for narcolepsy).

Caffeine, while not banned for the World Anti-Doping Agency, is a monitored substance.  It increases daytime alertness and may accelerate entrainment in new time zones when consumed in the morning (later ingestion may interfere with sleep induction) (Level A).

 

 

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Category: Misc

Title: Jet lag in athletes

Keywords: Travel, jet lag, circadian (PubMed Search)

Posted: 7/28/2012 by Brian Corwell, MD (Updated: 8/11/2022)
Click here to contact Brian Corwell, MD

Travel across time zones is regularly required of profession and collegiate athletes (in addition to the some of us professionally)

Jet lag is defined as insomnia or excessive daytime sleepiness/malaise following travel across at least 2 time zones

                Symptoms usually persist 1 day for each time zone crossed

The sleep schedule is primarily modulated by light and melatonin

Secretion of melatonin helps induce sleep

Exposure to light stimulates arousal and inhibits melatonin secretion

Who is at risk?

Those with more rigid sleep habits have more symptoms

“Morning” people have less difficulty flying eastward

“Evening” people have less difficulty flying west

However, overall, eastward travel causes the most severe symptoms which persist for up to 7 days (versus <3 days with westward travel)

                (The length of the day gets shortened and the circadian system must shorten to reestablish a normal rhythm. The human body demonstrates a natural tendency toward periods longer than 24 hours)

Those with higher levels of physical fitness adjust more quickly

Effects similar in men and women

Midday arrivals experience fewer symptoms than morning arrivals

Symptoms are less in those who have traveled the journey previously

Symptoms are less in those who had a shorter interval their last full nocturnal sleep in the departure city and their first full nocturnal sleep in the destination city


Category: Misc

Title: Contrast Allergy

Keywords: contrast media, iodine, shellfish (PubMed Search)

Posted: 6/16/2012 by Michael Bond, MD
Click here to contact Michael Bond, MD

Contrast Allergy:

Many patients will report that they have a allergy to iodinated contrast by saying that they are allergic to iodine

Iodine, itself, is not an allergen and is a required element for thyroid homrone production.  Plus could you imagine the hordes of people that would be having allergic reactions everyday when they add salt to their french fries.  Our EDs would be completely swamped.

A recent meta-analysis by Drs. Schabelman and Witting also showed the following:

  • The risk of a reaction to contrast ranges from 0.2% to 17% depending on the type used, and the severity of the reaction considered.
  • The risk of a reaction in patients with a seafood allergy is similar to that in patients with other food allergies or asthma.  Seafood is not unique to contrast media.
  • A history of prior reaction to contrast increases the risk of mild reactions to as high as 7-17% but has not been shown to increase the rate of severe reactions.
  • The risk of death due to contrast is estimated to be 0.0006 - 0.006%.

As we enter Crab eating season in Maryland, lets stop giving shellfish a bad name. A patent with any allergy is at increased risk, but shellfish is no higher a risk than those allergic to Strawberries.

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Category: Misc

Title: START Triage

Keywords: Triage, Mass Causality (PubMed Search)

Posted: 12/31/2011 by Michael Bond, MD (Updated: 8/11/2022)
Click here to contact Michael Bond, MD

START Triage

START triage is a simple system to implement that does not require any special equipment in order to determine who needs immediate, delayed or non-urgent care during a mass causality.

START stands for Simple Triage And Rapid Treatment. Patients are triaged based on 4 factors:

  • Ability to walk away from the scene
  • Respiration > or < 30 respirations per minute
  • Pulse (radial pulse present or not) or Capillary refill > or < 2 seconds
  • Mental Status – ability to follow simple commands or not

The steps are:

  1. If a patient can leave the scene they are minor and do not need immediate help. Category GREEN
  2. If there are no respirations or respirations > 30 they require immediate care Category RED
  3. Otherwise check pulse. If pulse is absent or capillary refill > 2 seconds they require immediate care Category RED
  4. Otherwise check mental status.  If they are not able to follow commands they need immediate care.  Category RED
  5. If they can follow commands they are delayed treatment. Category YELLOW

So those that can leave are green, those that do not meet any of the START criteria are YELLOW, and those with any of the four factors are RED or DEAD.


Category: Misc

Title: A Weird and Unusual Symptom

Posted: 10/24/2011 by Rob Rogers, MD (Updated: 8/11/2022)
Click here to contact Rob Rogers, MD

Weird and Unusual Symptoms

Bet you didn't know that severe and intense pruritus of the nostrils, known as Wartenberg's symptom, is an uncommon but characteristic symptom of a brain tumor.

Etiologies include astrocytoma, glioblastoma, oligodendroglioma, medulloblastoma, and metastatic tumors.

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Category: Misc

Title: Wound Repair

Keywords: Wound, Repair (PubMed Search)

Posted: 7/30/2011 by Michael Bond, MD
Click here to contact Michael Bond, MD

Wound Repair

A pearl last year addressed the irrigation of wound and the fact that the type of fluid (sterile versus tap water) does not affect infection rates but rather the volume of irrigation is most important.

Sterile versus unsterile gloves have also been studied, and it turns out that clean unsterile gloves have the same rate of infection as sterile gloves but come with a substantial cost savings.

When caring for a contaminated wound it is most important to remove any gross contamination, and then irrigate the wound as much as possible.  A 20 mL syringe with an 18G angio-catheter provides the proper pressure to remove debris without causing tissue damage. The wound can then be closed wearing the gloves that are most comfortable or accessible to you.

Finally, from a medicolegal standpoint it is always best to inform the patient that you have tried to remove all of the contamination but there is still a chance that the wound can get infected. 


Category: Misc

Title: Dose of Epinephrine for Anaphylaxis-"Titrate to Life"

Keywords: Epinephrine (PubMed Search)

Posted: 11/15/2010 by Rob Rogers, MD (Updated: 8/11/2022)
Click here to contact Rob Rogers, MD

Dose of Epinephrine for Patients with Anaphylaxis

Many of us are familiar with 0.3-0.5 mg IM of 1:1,000. Important to give IM and not SC.

In severe cases, consider IV Epinephrine:

  • Take 1 mg of crash cart Epinephrine (1:10,000) and inject into 1 liter of normal saline
  • Start drip at 1 cc/min which is 1 microgram/min
  • "Titrate to life" (i.e. titrate up or down according to severity)

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Category: Misc

Title: Pneumoperitoneum on CXR and CT

Keywords: Pneumoperitoneum, CXR, CT (PubMed Search)

Posted: 7/12/2010 by Rob Rogers, MD (Updated: 8/11/2022)
Click here to contact Rob Rogers, MD

Pneumoperitoneum on CXR and CT

Pneumoperitoneum may be seen on an upright CXR up to 7 days after laparoscopic abdominal surgery/laparotomy and may be seen on abdominal CT for as long as three weeks after surgery. 


Category: Misc

Title: TSH test

Posted: 6/14/2010 by Rob Rogers, MD (Updated: 8/11/2022)
Click here to contact Rob Rogers, MD

 

Submitted on behalf of Dr. Michael Abraham

Thyrotropin (TSH) 

  • Different types of test available:
    • The first tests available were radioimmunoassay. 
    • The next type of test available is the immunometric test.
  • As each test is developed there has been a trend to use the term ‘generation’ for a 10 fold increase in sensitivity. 1
  • Indications for ordering in the ED:   Hypothyroidism, Graves Disease, Hashimoto’s Thyroiditis, Thyroid storm.

 

  • Diagnostic Accuracy
    • The original TSH benchmark was the ability to measure euthyroid (0.4 – 4mIU/L) from very low (<0.01 mIU/L) which is suggestive of Graves disease. 
    • Most new tests have a functional sensitivity of <0.02mIU/L. 
    • The clinical sensitivity and specificity have to be determined by each laboratory’s staff. This requires testing of samples over a 6-8 week period as should include a sample of the population that is being tested.2
  • Average turnaround time to complete test: 
    • The tests are mainly run on large lab analyzers. There are many commercially available tests the turnaround time is dependent on the manufacturer of the machine.

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