Keywords: hyponatremia, maintenance fluid (PubMed Search)
Wang et al. Isotonic Versus Hypotonic Maintenance IV Fluids in Hospitalized Children: A Meta-Analysis. Pediatrics 2014; 133;105.
Keywords: Pediatrics, head lice (PubMed Search)
Head lice infestation is a common problem in the United States with treatment costs estimated at 1 billion dollars and cases affecting millions of children each year. Many of these children present to the ED for care...lucky us! Traditional therapies containing permethrin and pyrethrins are having increased rates of treatment failure likely secondary to increasing resistance and medication noncompliance. The typical first line agents require multiple doses. There are safety concerns regarding therapies that contain malathion and lindane in children. Is there another option? Topical ivermectin 0.5% lotion applied to scalp in a single dose has been shown to be effective and safe for treatment of head lice infestation in children older than 6 months. It was FDA approved at the end of 2012. Considerations include cost. Sklice lotion is expensive!
The NEJM article was considered an "editors pick" by the AAP as one of the best articles of 2012-2013.
1. Pariser DM, Meinking TL, Bell M, et al. Topical 0.5% ivermectin lotion for treatment of head lice. N Eng J Med. 2012; 367(18):1687-1693
2. Wright, T. Topical Ivermectin: a new treatment for head lice. AAP Grand Rounds, Feb 2013, Vol 29(2)
3. Frankowski BL, et al. Head Lice. Pediatrics. 2010; 126:392-404
4. Meinking TL, et al. Head Lice. Pediatric Dermatology. 2010; 27(1):19-24
Wang CJ, et al. Quality-of-care indicators for children with sickle cell disease. Pediatrics. 2011;128:484.
Berini JC, et al. Fatal hemolysis induced by Ceftriaxone in a child with sickle cell anemia. 1995;126:813.
Keywords: trauma, cardiac arrest, return of spontaneous circulation (PubMed Search)
Keywords: Intussusception, abdominal pain, fever (PubMed Search)
Case: A 3 year 9 month female presents with fever to 39.4 C and intermittent abdominal pain worsening over 2 days. The patient had been tolerating food and had no change in her bowel habits. Based on the imaging below, what is your diagnosis and treatment?
Answer: Intussusception. This patient failed air reduction enema and was taken the OR. No bowel ischemia was found. The ilium was inside of the colon at the ileocecal valve. There was significant mesenteric lymphadenitis noticed. The patient recovered and was discharged later that day.
The x-ray above shows a soft tissue mass under the liver projection in the RUQ that can be suggestive of intussusception in the appropriate case. The second x-ray done during attempted air reduction shows air surrounding a dense area on the right side. Ultrasound, however, has become the gold standard. The ultrasound image shows the classic target sign of hyperechoic compressed loop of bowel telescoping within a hypoechoic edematous outer loop of bowel.
A few other important facts:
The median age of presentation is 32 months, with many presenting before 12 month.
Abdominal pain and/or crying was seen in 95% of cases. 66% had vomiting, 28% had fever, and 27% had bloody stools.
Causes included 29% with enlarged mesenteric lymph nodes (followed by GJ tube obstruction and meckels diverticulium)
30% have concurrent infections (URI and gastroenteritis being most common)
91% 1st time success rates with air contrast enema
*The above percentages were taken from the article referenced, which is a retrospective review done at a tertiary pediatric center.
Lochhead et al. Intussusception in children presenting to the emergency department. Clinical Pediatrics 2013 52:1029.
Keywords: cough, upper respiratory infection, children, honey (PubMed Search)
How many times have you been frustrated in the peds ED when you have a child with a URI that has a significant night time cough and you feel like you have nothing to offer them for symptom control? The parent is frustrated because the child is not sleeping which means they are not sleeping and they are looking at you for help. We all know that OTC cough and cold medications are not helpful and may be harmful in children <2 yrs old and should be used with caution in children <6 yrs old. So what can you do? You can recommend a course of HONEY at night. Of course this does not apply to children < 1 yr who are at increased risk of botulism. A recent double-blind placebo-controlled trial published in Pediatrics in 2012 demonstrated reduced night time cough and subjective improved sleep quality in children age 1-5 who were given honey compared to placebo. This study supports previous less rigorous publications that found honey was an effective remedy on cough in children. Mechanism for honey's beneficial effect on cough is unknown but possibly related to close anatomic relationship between sensory nerve fibers that initiate cough and gustatory nerve fibers that taste sweetness. Of note, a recently published survey in Pediatric Emergency Care revealed that 2/3 of parents were unaware of the FDA guidelines regarding OTC cough and cold remedies in children! After you recommend HONEY for night time cough, take an extra minute and educate your parents about the potential dangers of cough and cold medicines in small children!
Cohen A, Rozen J, Kristal H, et al. Effect of honey on nocturnal cough and sleep quality: a double-blind, randomized, placebo-controlled study. Pediatrics. 2012; 130(2): 465-471.
Varney SM, et al. Pediatr Emerg Care. 2012; 28(9): 883-885
Food and Drug Administration. Using Over-The-Counter Cough and Cold Products in Children. Available at http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm048515.htm
Keywords: skull fracture (PubMed Search)
Pediatric patients with an isolated skull fracture and normal neurological exam have a low risk of neurosurgical intervention and outpatient follow up may be appropriate (assuming no suspicion of abuse and a reliable family). In a study published in 2011, a retrospective review over a 5 year period at a level 1 trauma center showed that 1 out of 171 admitted patients with isolated skull fractures developed vomiting. This patient had a follow up CT showing a small extra-axial hematoma that did not require intervention. 58 patients were discharged from the ED within 4 hours.
You can also check out another recent article published in Annals of Emergency Medicine on the same topic this month!
Rollins et al. Neurologically intact children with an isolated skull fracture may be safely discharged after brief observation. Journal of Pediatric Surgery. Volume 26. Issue 7. 2011.
Mannix et al. Skull Fractures: Trends in Management in US Pediatric Emergency Departments. Annals of Emergency Medicine. Volume 64. Issue 4. 2013.
Keywords: Omphalitis, necrotizing fasciitis, umbilical cord (PubMed Search)
Should you be concerned about erythema around the umbilical stump?!
Often parents will bring their neonate to the ED with concerns about the umbilical cord and it is just a simple granuloma or normal detachment. But is it omphalitis???
Omphalitis incidence is low in developed countries, but that means it’s easier, and no less catastrophic, to miss!
Omphalitis is a superficial cellulitis of the umbilical cord, but 10-16% progress to necrotizing fasciitis of the abdominal wall!!!
Always ADMIT and consider consulting surgery early in case of rapid progression…
Most often polymicrobial and should be treated with:
Should notice improvement within 12-24 hours, so if don’t or begin to observe
CONSULT SURERY for concern of necrotizing fasciitis which has a mortality rate of close to 60%!!!
Keywords: orthopedics, compartment syndrome (PubMed Search)
We have learned how to diagnose compartment syndrome in adults, but how do you determine the early warning signs in a nonverbal or even frightened child?
Rising compartment pressures are related to increasing anxiety and agitation in children. A Boston study in 2001 showed that increasing pain medication requirements were detected 7 hours earlier than a vascular exam change. 90% of the patients with compartment syndrome in this study reported pain, but only 70% had another ‘P” (pallor, parasthesia, paralysis or pulselessness).
This has led to the proposal of the 3 “A”s for early identification of compartment syndrome in children: increasing anxiety, agitation and analgesia requirement.
Noonan and McCarthy. Compartment Syndrome in Pediatric Patients. Journal of Pediatric Orthopedics. Vol 30. No 2. March 2010.
Keywords: laceration, suture, absorbable (PubMed Search)
A facial laceration on a child can present a unique challenge which is not limited to the initial visit. The traditional teaching has been to use nonabsorbable sutures and have the patient return in 5 days for removal. A recent study compared the cosmetic outcome of linear facial lacerations 1 to 5 cm that were closed with either Ethicon fast absorbing surgical gut or monocryl nonabsorbable sutures. Patients were randomized and returned to the ED in 4-7 days and 3-4 months. Scars were assessed by caregivers and blinded physicians. Results showed that caregivers preferred absorbable sutures. Visual analog scores as given by caregivers were not statistically different between the 2 groups at the 3 month mark. The blinded physicians did give better cosmetic outcome scores to the absorbable suture group which differs from previous studies that had shown equivocal results. Of note, all absorbable sutures were no longer visible after 14 days.
Bottom line: Try absorbable sutures the next time you are suturing a child and the parents may be happier and you will not have to try and take out your sutures from a squirming, screaming child.
Luck et al. Comparison of Cosmetic Outcomes of Absorbable Versus Nonabsorbable Sutures in Pediatric Facial Lacerations. Pediatric Emergency Care. Vol 29. No 6. 2013.
Clinically important traumatic brain injuries are rare in children. The PECARN study provides decision rules for when to avoid unnecessarily obtaining a CT for children who have suffered head trauma.
For children < 2 years old: <0.02% risk of clinically important TBI
For children > 2 years old: <0.05% risk of clinically important TBI
Kuppermann N, et al. Pediatric Emergency Care Applied Research Network. Identification of childrent at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study. Lancet 2009 Oct 3;374(9696):1160-70.
Keywords: sedation, pain management (PubMed Search)
Cringing at the thought of sewing up another screaming 2 year old?
Consider intranasal fentanyl.
Who: Young, otherwise healthy pediatric patients undergoing minor procedures (laceration repair, fracture reduction/splinting, etc...)
What: Fentanyl (2mcg/kg)
When: 5 minutes pre-procedure
Why: More effective than PO, less invasive than IV while being equally efficacious.
How: Use an atomizer, splitting the dose between each nostril.
Keywords: lactate, sepsis, pediatric (PubMed Search)
Lactate is commonly used in the adult ED when evaluating septic patients, but there is a lack of literature validating its use in the pediatric ED. Pediatric studies have suggested that in the ICU population, elevated lactate is a predictor of mortality and may be the earliest marker of death.
A retrospective chart review over a 1 year period showed that one elevated serum lactate correlated with increased pulse, respiratory rate, white blood cell count and platelets. Serum lactate had a negative correlation with BUN, serum bicarbinate and age. Elevated lactate levels were higher for admitted patients. However, the mean serum lacate level was not statistically different between those diagnosed with sepsis and those that were not.
The study included 289 patients less then 18 years who had both blood cultures and lactate drawn. This community hospital had a sepsis protocol in place that automatically ordered a lactate with blood cultures. Only previously healthy children were included.
The study is limited by its small sample size and overall low lactate levels. Despite having a protocol in place, only 39% of patients who had blood cultures drawn had lactate levels available for analysis. The mean serum lacate in this study was 2.04 mM indicating that the study population may not have been sick enough to determine mortality implications. There were no serial measurements.
Bottom line: Consider measuring serum lacate in your pediatric patient with suspected sepsis. Pediatric ICU literature does suggest that an serum lactate as low as 3mM is associated with an increased mortality in the ICU.
Reed et al. Serum Lactate as a Screening Tool and Predictor of Outcome in Pediatric Patients Presenting to the Emergency Department With Suspected Infection. Pediatric Emergency Care. 2013; Vol 29: 787-791.
Risk stratisfication score introducted by Maden Samuel in 2002.
The Pediatric Appendicitis Score had a sensitivity of 1, speciificity of 0.92, positive predictive value of 0.96, and negative predictive value of 0.99
Scores of 4 or less are least likely to have acute appendicitis, while scores of 8 or more are most likely.
Pediatric Appendicits Score. Samuel, M. J Pedia Surg.37:877-888. 2002.
Keywords: NIV, intubation (PubMed Search)
Pediatrics Text 19th edition, Nelson
Infant lumbar puncture is often difficut and may require repeated attempts. The traditional body positioning is lateral decubitus. Previous studies have examined the saftey of having the patient in a sitting position, and neonatal studies have suggested that the subarachnoid space increases in size as the patient is moved to the seated position. A study by Lo et al published last month looked to see if the same held true in infants.
50 healthy infants less then 4 months old had the subarachnoid space measured by ultrasound between L3-L4 in 3 positions: lateral decubitus, 45 degree tilt and sitting upright.
This study found that the size of the subarachnoid space did not differ significantly between the 3 positions. Authors postulated that a reason for increase sitting LP success rate that had been reported in anestesia literature with tilt position could be due to other factors such as increased CSF pressure, intraspinous space widening or improved landmark identification.
Sitting or Tilt Position for Infant Lumbar Puncture Does Not Increase Ultrasound Measurements of Lumbar Subarachnoid Space Width. Pediatr Emer Care 2013;29: 588-591.
Ultrasound findings of appendicitis