UMEM Educational Pearls

Category: Toxicology

Title: Intranasal Naloxone

Keywords: naloxone, intranasal (PubMed Search)

Posted: 12/10/2009 by Bryan Hayes, PharmD (Updated: 12/9/2022)
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When IV access is not immediately available and you don’t want to rely on the erratic absorption of IM administration, naloxone can be given by the intranasal (IN) route.
 
Kinetics are similar to IV: Onset 1-2 minutes, duration 40-50 minutes.
 
Dose is the same as IV: Up to 1 mL (0.4 mg) can be given in each nostril.
 
Advantage of needleless administration.
 
To use: Draw up dose of nalxone and simply add an atomizer to the end of a syringe (see picture).  Administer half of final dose in each nostril.
 
Atomizers are now available in the UMMC ED.


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