UMEM Educational Pearls

Category: Trauma

Title: Does empiric high dose cryoprecipitate added to MHP improve survival?

Keywords: transfusion, mass hemorrhage protocol, cryoprecipitate (PubMed Search)

Posted: 10/14/2023 by Robert Flint, MD (Emailed: 10/29/2023) (Updated: 6/24/2024)
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This large UK and US study looked at the addition of high dose cryoprecipitate to mass transfusion protocols and found:  “Among patients with trauma and bleeding who required activation of a major hemorrhage protocol, the addition of early and empirical high-dose cryoprecipitate to standard care did not improve all cause 28-day mortality.”


Davenport RCurry NFox EE, et al. Early and Empirical High-Dose Cryoprecipitate for Hemorrhage After Traumatic InjuryThe CRYOSTAT-2 Randomized Clinical TrialJAMA. Published online October 12, 2023. doi:10.1001/jama.2023.21019