Keywords: naloxone, opioid overdose (PubMed Search)
Posted: 3/10/2015 by Bryan Hayes, PharmD
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In the midst of an unprecedented opioid epidemic, there have been considerable efforts to expand access to naloxone (Doyon S, et al. J Med Toxicol 2014;10:431-4). If the situation arises when you need to write a prescription for it, here's how:
Option 1: Naloxone vial and needle traditional IM/SQ using 0.4 mg/mL injection vial and needles (least expensive $40, FDA approved)
Naloxone 0.4 mg/mL single dose vial and 3 cc, 23 g, 1 inch syringes, #2 each
SIG: Inject 1 mL intramuscularly upon signs of opioid overdose. May repeat X 1. Call 911.
Option 2: IMS/Amphastar 2 mg/2 mL prefilled syringe and mucosal atomization device ($95/kit, products FDA approved but intranasal administration is off-label)
Naloxone 2 mg/2 mL prefilled syringe and intranasal atomizer device, #2 each
SIG: Spray one-half of syringe (1 mL) into each nostril upon signs of opioid overdose. May repeat X 1. Call 911.
Option 3: Evzio Autoinjector ($200-700 per Rx though many insurances cover it and the company has vouchers available, FDA approved in 2014, evzio.com/hcp)
Evzio 0.4 mg, #1 two-pack
SIG: Use as directed upon signs of opioid overdose. May repeat X 1. Call 911.
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