UMEM Educational Pearls

Category: Trauma

Title: IM TXA?

Keywords: TXA, intramuscular, pre-hospital (PubMed Search)

Posted: 3/28/2023 by Robert Flint, MD (Emailed: 4/9/2023) (Updated: 6/19/2024)
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This paper looks at the possibility of intramuscular tranexamic acid (TXA) administration. Pharmacologic studies support this route as giving correct drug bioavailability to control hemorrhage. Several London, England pre-hospital services have begun using intramuscular TXA for trauma patients when intravenous access cannot be quickly obtained. This paper suggests 500 mg intramuscular injection dosing. 

References

Prehospital tranexamic acid for trauma victims

Kazuhiko Omori  Ian Roberts

Journal of Intensive Care volume 11, Article number: 12 (2023)