UMEM Educational Pearls

Category: Trauma

Title: Whole Blood vs Blood products in trauma resuscitation

Keywords: trauma, whole blood, blood products, resucitation (PubMed Search)

Posted: 10/2/2022 by Robert Flint, MD (Updated: 4/24/2024)
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A fourteen center study enrolling 1623 trauma patients (53% penetrating) comparing cold-stored whole blood vs. blood component products found no difference in AKI, thromboembolism, or pulmonary complications. And more interestingly, patients receiving whole blood were 48% less likely to die than those receiving standard blood component products. Add this data point to a growing trend toward cold-stored whole blood for trauma patients.


Hazelton, J., et al. “Use of Cold-Stored Whole Blood is Associated with Improved Mortality in Hemostatic Resuscitation of Major Bleeding A Multicenter Study”  Annals of Surgery October 2022, Volume 276, Issue 4, p. 579-88.