Serious outcomes after overdose or nonintentional exposures to medications used to treat depression have risen dramatically over the past 15 years. Morbidity and mortality associated with drugs used to treat depression were studied utilizing the National Poison Data System from 2000-2014. Tricyclic and monoamine oxidase inhibitor medications were associated with the highest morbidity and mortality. Newer agents such as Lithium, venlafaxine, bupropion, quetiapine, olanzapine, ziprasidone, valproic acid, carbamazepine, and citalopram were also associated with higher mortality indices.
Morbidity and Mortality Associated With Medications Used in the Treatment of Depression: An Analysis of Cases Reported to U.S. Poison Control Centers, 2000-2014. Nelson C, Spyker DA. Am J Psychiatry. 2017 May 1;174(5):438-450. doi: 10.1176/appi.ajp.2016.16050523. Epub 2017 Jan 31.