UMEM Educational Pearls


30 year-old female with complains of night sweats and painful lesions on her fingertips. What’s the diagnosis and list some things to have in the differential diagnosis?


Answer: Osler Nodes

Osler notes are painful, palpable, and erythematous lesions secondary to the deposition of immune-complexes within the pads of digits.

Although classically associated with infective endocarditis, some authors claim that it may be seen in only 10-23% of confirmed cases. Therefore the differential diagnosis should also include:

  • Bacteremia
  • Disseminated gonococcal infection
  • Lupus
  • Vasculitis
  • Drug-induced


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