UMEM Educational Pearls

Category: Toxicology

Title: Highlights from the new Salicylate Toxicity Management Guideline

Keywords: salicylate, aspirin, toxicity, sodium bicarbonate (PubMed Search)

Posted: 7/10/2013 by Bryan Hayes, PharmD (Emailed: 7/11/2013) (Updated: 7/11/2013)
Click here to contact Bryan Hayes, PharmD

In June 2013 the American College of Medical Toxicology (ACMT) released a Guidance Document on the Management Priorities in Salicylate Toxicity. Here are some key highlights:

  • Continuous IV infusion of sodium bicarbonate is indicated even in the presence of mild alkalemia from the early respiratory alkalosis.
  • Euvolemia is important.
  • If intubation is required, administration of sodium bicarbonate by IV bolus at the time of intubation in a sufficient quantity to maintain a blood pH of 7.45-7.5 over the next 30 minutes is a reasonable management option during this critical juncture.
  • Once airway control has been established, it is imperative that the increased minute ventilation and low PCO2 usually seen with salicylate intoxication are maintained.
  • A salicylate concentration approaching 100 mg/dL warrants consideration of hemodialysis in the acute toxicity setting (40 mg/dL for chronic toxicity). Consult nephrology well before these threshold levels.

The full document can be accessed here.

The Poison Review blog by Dr. Leon Gussow discusses the guidance document here.

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