Keywords: strychnine, seizure, tetanus (PubMed Search)
Posted: 5/7/2013 by Bryan Hayes, PharmD
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Strychnine poisoning is still occasionally found in rat poisons and in adulterated street drugs and herbal products. The typical symptoms are involuntary, generalized muscular contractions resulting in neck, back, and limb pain. The contractions are easily triggered by trivial stimuli (such as turning on a light) and each episode usually lasts for 30 seconds to 2 minutes, for 12 to 24 hours. Classic signs include opisthotonus, facial trismus, and risus sardonicus.
Differential diagnosis includes:
Chan Y. Chapter 112. Strychnine. In: Chan Y, ed. Goldfrank's Toxicologic Emergencies. 9th ed. New York: McGraw-Hill; 2011. http://www.accesspharmacy.com/content.aspx?aID=6528306. Accessed May 7, 2013.
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