UMEM Educational Pearls


64 year-old male with no past medical history presents complaining of chronic weight-loss and diffuse chest pain; CXR is shown below. What's the diagnosis, and what other disease(s) may present this way?



Answer: Sclerotic bone (osteoblastic) metastasis secondary to prostate cancer. The patient's CXR from 2 years prior is shown below for comparison.

Other malignancies associated with osteoblastic metastasis:

  • Breast cancer
  • Colon cancer (mucinous adenocarcinoma)
  • Lymphoma
  • Carcinoid
  • Neuroblastoma
  • Prostate cancer (#1 cause)


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