UMEM Educational Pearls

Category: Cardiology

Title: PPIs and clopidogrel

Keywords: clopidogrel, acute coronary syndrome, proton pump inhibitors (PubMed Search)

Posted: 6/12/2011 by Amal Mattu, MD (Updated: 12/2/2023)
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Proton pump inhibitors should be avoided in patients being treated with clopidogrel. PPIs appear to attenuate the effect of clopidogrel, and there's even some suggestion that the addition of PPIs to the medication regimen of patients taking clopidogrel may be associated with an increased risk of rehospitalization or death.


ACC/AHA Focused Update of the 2007 Non-STE-ACS Guidelines (Circulation 2011)