UMEM Educational Pearls

Category: Vascular

Title: Got Lytics?

Keywords: Pulmonary Embolism (PubMed Search)

Posted: 6/7/2010 by Rob Rogers, MD (Updated: 4/13/2024)
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Thrombolytic Therapy for Pulmonary Embolism

Current, FDA-approved thrombolytic therapy for PE:

  • tPA 100 mg over two hours-infusion
  • Heparin drip should be turned off during tPA infusion and turned back on ONLY after PTT has fallen to 2 X normal
  • Other drugs are being used-like Tenecteplase (TNKase), but strictly speaking, not FDA approved for thrombolysis of PE
  • Most studies to date do not show that catheter-based delivery of lytics is safer than systemically administered lytics