Category: Toxicology
Keywords: thyroid, hypothyroid, hyperthyroid (PubMed Search)
Posted: 12/14/2007 by Fermin Barrueto
(Updated: 10/15/2024)
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Lithium: Hypothyroidism (5-15% of pts) and goiter (37% of pts), mechanism unclear
Amiodarone (37% Iodine by weight): Hyper or Hypothroidism
Beta-Blockers: by blocking peripheral conversion of T4 to T3 cause hypothyroidism
Corticosteroid: same as beta-blockers but can also cause transient thyrotoxicosis (Jod-Basedow effect)
Iodine, Iodinated contrast, radiactive iodine all can cause hypothyroidism but iodinated contrast material can actually induce thyrotoxicosis and thyroid storm from unknown mechanism.
Category: Toxicology
Keywords: ondansetron,metoclopramide (PubMed Search)
Posted: 12/7/2007 by Fermin Barrueto
(Updated: 10/15/2024)
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Everything you need to know about anti-emetics, mechanism of action, potency and toxicity:
1) 5-HT3 Blockers - Ondansetron, Granistron
- The most potent anti-emetic, only toxicity is really cost
2) Dopamine Blockers - Metoclopramide
- Can titrate to high doses, causes dystonia, akathisia and mild QT prolongation
3) Anticholinergic - Promethazine, meclizine, diphenhydramine
- Cannot titrate, most sedating, urinary retention in elderly, mild QT prolongation
Category: Toxicology
Keywords: radiocontrast, nephropathy, renal failure (PubMed Search)
Posted: 11/29/2007 by Fermin Barrueto
(Updated: 10/15/2024)
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Category: Toxicology
Keywords: Food Poisoning, tetrodotoxin, ciguatera toxin (PubMed Search)
Posted: 11/22/2007 by Fermin Barrueto
(Updated: 10/15/2024)
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A short list of some of the unique food poisonings and the toxicologic effects:
Category: Toxicology
Keywords: sulfonylureas, octreotide, hypoglycemia (PubMed Search)
Posted: 11/8/2007 by Fermin Barrueto
(Updated: 10/15/2024)
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Sulfonylureas
Fasono et al. Comparison of Octreotide and Standard Therapy Versus Standard Therapy Alone for the Treatment of Sulfonylurea-Induced Hypoglycemia. Ann Emerg Med 2007 Aug 29.
Category: Toxicology
Keywords: anticonvulsant, carbamazepine, seizure (PubMed Search)
Posted: 11/2/2007 by Fermin Barrueto
(Updated: 10/15/2024)
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Carbamazepine
Category: Toxicology
Keywords: SSRI, serotonin, toxicity (PubMed Search)
Posted: 10/25/2007 by Fermin Barrueto
(Updated: 10/15/2024)
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SSRI Toxicity
Things to watch for in patients that are taking SSRI:
Category: Toxicology
Keywords: Gamma-Hydroxybutyrate, GHB, Liquid X, date rape, overdose (PubMed Search)
Posted: 10/18/2007 by Fermin Barrueto
(Updated: 10/15/2024)
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GHB
Category: Toxicology
Keywords: valproic acid, poisoning, carnitine (PubMed Search)
Posted: 10/11/2007 by Fermin Barrueto
(Updated: 10/15/2024)
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Valproic Acid (Depakote) - Increased use for both seizure disorder, migraine prophylaxis and bipolar disorder - Causes hyperammonemia with or without hepatic insufficiency (Liver enzymes could be normal!) - Hyperammonemia can occur at therapeutic concentrations and overdose - If the patient is sedated and has hyperammonemia, consider carnitine therapy antidotal - Carnitine IV or PO: 50-100 mg/kg bolus or divided bid, safe to give
Category: Toxicology
Keywords: Isopropanol, toxic alcohol, poisoning (PubMed Search)
Posted: 10/4/2007 by Fermin Barrueto
(Updated: 10/15/2024)
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Category: Toxicology
Keywords: ciguatera, poisoning, fish (PubMed Search)
Posted: 9/27/2007 by Fermin Barrueto
(Updated: 10/15/2024)
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Category: Toxicology
Keywords: ethanol, withdrawal, benzodiazepines (PubMed Search)
Posted: 9/18/2007 by Fermin Barrueto
(Emailed: 9/20/2007)
(Updated: 10/15/2024)
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0709201013_ciwa-ar.pdf (10 Kb)
Category: Toxicology
Keywords: Hyperglycemia, diabetes, poisoning (PubMed Search)
Posted: 9/13/2007 by Fermin Barrueto
(Updated: 10/15/2024)
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Category: Toxicology
Keywords: Fish, scombroid, seafood poisoning (PubMed Search)
Posted: 9/6/2007 by Fermin Barrueto
(Updated: 10/15/2024)
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Category: Toxicology
Keywords: pyridium, methemoglobinemia, methylene blue (PubMed Search)
Posted: 8/30/2007 by Fermin Barrueto
(Updated: 10/15/2024)
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Category: Toxicology
Keywords: Colchicine, toxicity, poisoning (PubMed Search)
Posted: 8/23/2007 by Fermin Barrueto
(Updated: 10/15/2024)
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Category: Toxicology
Keywords: lidocaine, allergic reaction, toxicity (PubMed Search)
Posted: 8/16/2007 by Fermin Barrueto
(Updated: 10/15/2024)
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Category: Toxicology
Keywords: Chest radiograph, poisoning, amiodarone (PubMed Search)
Posted: 8/9/2007 by Fermin Barrueto
(Updated: 10/15/2024)
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Category: Toxicology
Keywords: opioids, adverse drug effect, methadone (PubMed Search)
Posted: 8/2/2007 by Fermin Barrueto
(Updated: 10/15/2024)
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Category: Toxicology
Keywords: Nerve agents, organophosphates, blistering agents (PubMed Search)
Posted: 7/26/2007 by Fermin Barrueto
(Updated: 10/15/2024)
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