UMEM Educational Pearls

Category: Toxicology

Title: Methemoglobinemia

Keywords: pyridium, methemoglobinemia, methylene blue (PubMed Search)

Posted: 8/30/2007 by Fermin Barrueto, MD (Updated: 7/22/2024)
Click here to contact Fermin Barrueto, MD

- Classic Clinical Finding: Cyanosis out of proportion to clinical symptoms (look real blue but not SOB) - Causative Agents: Benzocaine (and other local anesthetics), dapsone, nitrites, phenazopyridine (Pyridium) - When do you treat: significant tissue hypoxia (MI, CVA, Dysrhythmias), and if MetHb >20% asymptomatic - Treatment: Methylene Blue 1-2 mg/kg (0.1 -0.2 mL/kg of 1% methylene blue) over minutes