UMEM Educational Pearls

Category: Geriatrics

Title: lab abnormalities with age

Keywords: geriatric, elderly, laboratory (PubMed Search)

Posted: 10/25/2009 by Amal Mattu, MD (Updated: 7/1/2022)
Click here to contact Amal Mattu, MD

A handful of lab abnormalities occur as a normal part of aging. Elderly patients will often demonstrate the following lab abnormalities without these indicating pathology:
1. ESR increases...use the following correction factor: top normal ESR < (age + 10)/2
2. creatinine falls
3. alkaline phosphatase may be elevated 2-3 fold
4. urinalysis may show asymptomatic pyuria or bacteriuria
5. ABGs demonstrate lower PaO2s and elevated A-a gradients
6. the top normal D-dimer level elevates slightly
7. the top normal BNP level elevates slightly
8. the ECG may show a first degree AV block, poor R-wave progression, leftward axis, and PVCs