UMEM Educational Pearls

Oseltamivir (Tamiflu)

  • Has low protein binding and does not inhibit CYP450 (resulting in a low incidence of drug interactions)
  • Requires dosage adjustment with creatinine clearance of < 30 ml/min
  • Does not require dosage adjustment in patients with liver failure or the elderly
  • Most common adverse effects are nausea and vomiting
  • Serious effects include anaphylaxis and skin reactions. Neuropsychiatric effects reported include hallucinations, delerium and abnormal behavior
  • It may be administered to infants and children due to the high potential morbidity associated with influenza


For complete indications and dosing: