UMEM Educational Pearls

Category: Misc

Title: G6PD Deficiency

Keywords: G6PD, Deficiency (PubMed Search)

Posted: 4/11/2009 by Michael Bond, MD (Updated: 6/25/2022)
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Glucose-6-Phosphate Dehydrogenase Deficiency

  • G6PD Deficiency is a genetic disorder which can cause hemolytic anemia when people with the disorder come into contact with drugs, food and other substances which cause oxidative stress.
  • It is the most common genetic enzyme deficiency.
  • G6PD is an inherited disorder with over 400 different known variants.
  • Oxidative stress can cause the premature distruction of RBC's due to the lack of the enzyme reduced glutathione which G6PD helps produce.
  • Drugs that are at high risk for causing hemolytic anemia in those with G6PD deficiency are:
    • NSAIDS (Asprin, Tylenol, Ibuprophen)
    • Quinolones
    • Sulfa drugs
    • Drugs metabolized known to cause blood or liver related problems or hemolysis
    • Primaquine
    • Nitrofurantoin
    • Glyburide
    • Dapsone

Also make sure that you are not G6PD deficiency if you are eating with Hannibal Lecter as Fava beans and other legumes can also cause an episode of hemolysis.

A good reference for G6PD deficiency is http://g6pddeficiency.org/index.php