Category: Toxicology
Keywords: serotonin (PubMed Search)
Posted: 3/26/2009 by Fermin Barrueto
(Updated: 12/12/2024)
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Serotonin is a neurotransmitter that has central and peripheral effects. It regulates the secretion of ADH from the hypothalamus and also controls the chemoreceptive trigger zone (CTZ) which induces emesis. Here are a list of medications categorized by the way they affect serotonin. Remember, any combination of these agonists could precipitate serotonin syndrome:
Enhance 5-HT synthesis: L-tryptophan
Direct HT agonists: Ergots, metoclopramide, sumatriptan, buspirone
Increase 5-HT release: amphetamines, cocaine, dextromethorphan, MDMA, L-dopa
Inhibit 5-HT breakdown: MAOIs, Linezolid
Inhibit 5-HT re-uptake: SSRIs (paxil), amphetamines, carbamazapine, tramadol, TCAs, citalopram, trazodone, lamotrigine, meperidine