A scoping review of literature involving norepinephrine use during cardiac arrest associated with a shockable rhythm found:
-evidence in animal and signal in human trials of improved myocardial and cerebral blood flow
-a suggestion of less re-arrest
There is not enough evidence comparing epinephrine to norepinephrine however this would be an excellent area of research with a theoretical advantage to norepinephrine.
References
Bouman, S.J., Baldussu, E., Franssen, G.H. et al. The effects of norepinephrine in shockable cardiac arrest, a scoping review. Scand J Trauma Resusc Emerg Med33, 155 (2025). https://doi.org/10.1186/s13049-025-01480-6
