UMEM Educational Pearls

Title: Antagonize Anticoagulation

Keywords: coumadin, vitamin K, anticoagulation (PubMed Search)

Posted: 6/19/2008 by Fermin Barrueto, MD (Updated: 3/26/2023)
Click here to contact Fermin Barrueto, MD

Here is a short list of medications that will actually prevent a patient from being anticoagulated by coumadin. These medications will make it difficult for the patient to reach therapeutic levels and need to be warned about this drug-drug interaction with coumadin:

Antacids
Antihistamines
Barbituates
Carbamazepine
Cholestyramine
Corticosteroids
Griseofulvin
OCPs
Phenytoin
Rifampin
Vitamin K

Reference: Goldfrank's Textbook of Toxicologic Emergencies, 6th Edition