UMEM Educational Pearls

Category: Toxicology

Title: Antagonize Anticoagulation

Keywords: coumadin, vitamin K, anticoagulation (PubMed Search)

Posted: 6/19/2008 by Fermin Barrueto, MD (Updated: 1/26/2022)
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Here is a short list of medications that will actually prevent a patient from being anticoagulated by coumadin. These medications will make it difficult for the patient to reach therapeutic levels and need to be warned about this drug-drug interaction with coumadin:

  • Antacids
  • Antihistamines
  • Barbituates
  • Carbamazepine
  • Cholestyramine
  • Corticosteroids
  • Griseofulvin
  • OCPs
  • Phenytoin
  • Rifampin
  • Vitamin K

Reference: Goldfrank's Textbook of Toxicologic Emergencies, 6th Edition