Order CBC, reticulocyte count, blood culture, CXR, and other testing as needed based on presentation
Admit patients with high fever, toxic appearance, infiltrate on CXR, hypoxia, tachypnea not explained by fever, poor intake/dehydration, severely abnormal CBC, history of S. pneumoniae sepsis, pain crisis + fever
Miller, Scott and Kusum Viswanathan. "Sickle Cell Anemia with Fever." Atlas of Pediatric Emergency Medicine, 3rd Edition, edited by Binita Shah, McGraw-Hill, 2019, 510-511.