Keywords: Bupropion, Seizure, Cardivascular instability (PubMed Search)
Posted: 6/2/2016 by Kathy Prybys, DO
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Bupropion (Wellbutrin, Zyban) is one of the most frequently prescribed antidepressants and smoking cessation agents. A lesser incidence of undesirable side effects such as weight gain and sexual dysfunction when compared to other antidepressants lends to its popularity. Bupropion's mechanism of action is only partially understood but it is known to be a norepinephine dopamine reuptake inhibitor and anticholinergic receptor blocker at certain nicotinic receptors. Bupropion has a monocyclic structure similar to amphetamines. Seizures are a major concern in overdose. When first released, Bupropion was initially withdrawn from the market due to its narrow therapeutic window with seizures occurring at doses as low as 450 mg.
Life threatening Bupropion ingestion, Is there a role for intravenous fat emulsion? Livshits Z, Feng L, et al. Basic & Clinical Toxicology & Pharmacology, 2011, 109. 418-22.
Incidence and onset of delayed seizures after overdoses of extended release Bupropion. Starr P, Klein-Schwartw W, et al. Am Journal EM, 2009 Oct(27)8: 911-15.
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