UMEM Educational Pearls

Category: Cardiology

Title: Giant Cell Myocarditis

Posted: 6/28/2015 by Semhar Tewelde, MD (Updated: 7/17/2024)
Click here to contact Semhar Tewelde, MD

Giant Cell Myocarditis

Giant cell myocarditis (GCM) is an infrequent, but often fatal form of acute myocarditis that has been shown to respond to cyclosporine-based immunosuppressive therapy

Even after heart transplantation GCM recurrence in the donor heart has been cited as high as 20% to 25%

Patients are surviving longer without transplantation because of efficacious medical therapy

A multi-institutional prospective data set revealed several novel findings in GCM:

·      Long-term immunosuppression appears capable of lengthening transplantation-free survival ~19 years beyond initial diagnosis

·      Cessation and/or reduction of immunosuppression are associated with GCM recurrence

·      Patients who developed cyclosporine associate renal failure were able to be switched to a sirolimus-based regimen


Maleszewski J, Orellana V, et al. Long-Term Risk of Recurrence, Morbidity and Mortality in Giant Cell Myocarditis. Am J Cardiol 2015;115:1733e1738