UMEM Educational Pearls

Category: Pediatrics

Title: Pediatric Migraine Therapy

Keywords: migraine, sodium valproate, headache (PubMed Search)

Posted: 6/19/2015 by Jennifer Guyther, MD
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Sodium valproate (VPA) had been studied and found to be effective in the adult population for migraines, but not in the pediatric population.  This article was a small (12 patient) retrospective study of pediatric migraine patients looking at pain scores before and after VPA administration.  Prior to VPA, patients received NSAIDs, dopamine antagonists, IV fluids and narcotics.  Mean pain reduction prior to VPA was 17%.  After VPA, pain scores were reduced by an additional 36%.


Sheridan, D, Sun, B, O’Brien, BS, and Hansen, M.  Intravenous Sodium Valproate for Acute Pediatric Headache.  The Journal of Emergency Medicine.  Article in Press.  Accepted February 2015.