UMEM Educational Pearls

  • Evidence-based guidelines recommend therapeutic hypothermia in adults following resuscitation from cardiac arrest.
  • Very few trials exist for children.
  • The most recently published study on the subject (New England Journal of Medicine, May 2015) was of 295 children aged 2 days to 18 years old, at 38 different childrens hospitals who underwent targeted temperature management. 
  • There was no significant difference in primary outcome between the hypothermia and normothermia groups.  One year survival and 28-day survival were similar, as were incidences of infection, serious arrhythmias, and use of blood products.
  • "In comotose children who survived out-of-hospital cardiac arrest, therapeutic hypothermia, as compared with therapeutic normothermia , did not confer a significant benefit in survival with a good functional outcome at 1 year."


Therapeutic Hypothermia after Out-of-Hospital Cardiac Arrest in Children. Mosler FW, et al. N Eng J Med 2015; 372:1898-1908. May 2015