UMEM Educational Pearls

Title: Levetiracetam (Keppra)

Category: Toxicology

Keywords: anticonvulsant, status epilepticus, keppra (PubMed Search)

Posted: 1/3/2008 by Fermin Barrueto (Updated: 11/22/2024)
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Levetiracetam

  • A new anticonvulsant that is 100% renally eliminated
  • Does not require therapeutic drug monitoring like phenytoin
  • The IV form does not cause skin necrosis or have cardiotoxicity like phenytoin
  • Is being investigated in benzodiazepine-refracory status epilepticus (1)
  • Fairly safe drug even in overdose (Barrueto et al ;) )

 

Knake et al. Intravenous levetriacetam in thetreatment of benzodiazepine-refractory status epilepticus. J Neurol Neurosurg Psychiatry 2007 Sept 26; Epub