Category: Pharmacology & Therapeutics
Keywords: antibiotic, IV, diarrhea (PubMed Search)
Many of the oral antibiotics prescribed in the ED have good bioavailability. So, a one-time IV dose before discharge generally won't provide much benefit.
In fact, a new prospective study found that a one-time IV antibiotic dose before ED discharge was associated with higher rates of antibiotic-associated diarrhea and Clostridium difficile infection.  One-time doses of vancomycin for SSTI before ED discharge are also not recommended (see Academic Life in EM post).
Though there are a few exceptions, if a patient has a working gut, an IV dose of antibiotics before ED discharge is generally not recommended and may cause increased adverse effects. An oral dose is just fine.
Follow me on Twitter (@PharmERToxGuy) or Google Plus (+bryanhayes13)