UMEM Educational Pearls

Category: Toxicology

Title: Ketorolac (Toradol) Toxicity - Need to Know

Keywords: NSAID, ketorolac, gastritis, renal failure (PubMed Search)

Posted: 12/20/2007 by Fermin Barrueto, MD (Updated: 6/24/2024)
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Ketorolac: an NSAID that gained popularity since it is not an opioid, has excellent anti-inflammatory/analgesic effects and is given IM or IV. Also has been used in renal colic secondary to smooth muscle relaxation (Prostaglandin mediated) in the ureters. You should know:

  • When given IV or IM still causes PUD and has caused GI perforations.
  • Renal Insufficiency is larger concern with this NSAID than others.
  • Consider misoprostol for GI complications.
  • Use for acute pain, limit the number doses given and don't prescribe for more than 3 days. I generally don't prescribe it at all, use another NSAID for outpatient treatment.


Corelli et al. Renal Insufficiency and ketorolac. Ann Pharmacother. 1993; 27(9): 1055-7