Only treat strep pharyngitis after confirmed via rapid antigen test or culture
Remember the rapid antigen test has high specificity, but low sensitivity. All negative rapid antigen tests should be followed up with a confirmatory culture
Traditionally, strep pharyngitis was treated with penicillin V, 250mg PO tid for children and 500 mg tid for adolescents. This was then changed to bid dosing.
Now, consider treating with amoxicillin, 50mg/kg once daily (max 1000mg). Once daily dosing and better taste improve compliance
