Keywords: Metformin, lactic acidosis (PubMed Search)
Posted: 7/17/2014 by Hong Kim, MD, MPH
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Metformin is the first line medication for the treatment of type II diabetes. A rare complication of chronic metformin use is MALA.
The association between metformin accumulation and development of lactic acidosis is controversial as patients with suspected MALA experience concurrent illnesses such as sepsis/septic shock, tissue hypoxia, and/or organ dysfunction (especially renal failure).
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