UMEM Educational Pearls

Category: Toxicology

Title: Methadone is Cardioprotective?

Keywords: methadone (PubMed Search)

Posted: 10/18/2012 by Fermin Barrueto, MD (Updated: 6/15/2024)
Click here to contact Fermin Barrueto, MD

Many who work in urban EDs and have a patient population that has a high rate of methadone use have probably wondered - why don't I see many STEMIs in the ED?

One study has actually attempted to answer the question - is methadone cardioprotective? Comparing 98 decedents with known long-term methadone exposure and compared autopsy coronary artery findings to match controls without, there was significant decrease in incidence of severe CAD:

5/98 Methadone Patients post-mortem had severe CAD vs 16/97 match controls

Better than a baby ASA, who knew?

[I thank Dr. Hoffman for citing this article to me]





Coronary artery disease and opioid use.

Marmor M, Penn A, Widmer K, Levin RI, Maslansky R.

Am J Cardiol. 2004 May 15;93(10):1295-7.