UMEM Educational Pearls

Title: Brugada Syndrome

Category: Cardiology

Keywords: Brugada syndrome (PubMed Search)

Posted: 9/23/2012 by Semhar Tewelde, MD
Click here to contact Semhar Tewelde, MD

Autosomal dominant inherited arrhythmic disorder characterized by mutation in sodium-channels

Arrhythmic events are often observed at rest or while asleep, resulting in VF and SCD

Diagnostic criteria consists of 2 parts: (1) ECG abnormalities (2) clinical characteristics

A. ECG abnormalities: incomplete or complete RBBB in right precordial leads (V1-V2) w/

Type I coved-type ST segment elevation and negative T wave

Type II saddle-back ST segment elevation followed by a positive or biphasic T wave

Type III ST segment elevation without meeting criteria for type I or II variants

B. Clinical characteristics: hx of VT/ VF, family hx of SCD or abnormal ECG, agonal respirations during sleep, or inducible VT/VF during EP study

Mizusawa Y, Wilde A. Brugada Syndrome. Circ Arrhythm Electrophysiol. 2012;5:606-616.