Keywords: sedation, dexmedetomidine (PubMed Search)
Posted: 4/26/2012 by Fermin Barrueto, MD
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Dexmedetomidine is an alpha2-agonist that has a similiar mechanism of action to clonidine. Short half-life and no respiratory depression make it possibly more effective than propofol in procedural sedation. Cost/Availability are the biggest barriers. Transient bradycardia is also possible but the actual incidence of clinically significant bradycardia is not yet elucidated.
I am still awaiting the first emergency department study looking at dexmedetomidine for procedural sedation.
A recent article actually brought up the possibility of utilizing it intranasally which could have some tantalizing pediatric applications.
A double-blind, crossover assessment of the sedative and analgesic effects of intranasal dexmedetomidine.
Yuen VM, Irwin MG, Hui TW, Yuen MK, Lee LH.
Anesth Analg. 2007 Aug;105(2):374-80.
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