Category: Critical Care
Keywords: uremia, bleeding, ddavp, estrogens, epogen, cryoprecipitate (PubMed Search)
Bleeding associated with uremia is a spectrum, from mild cases (e.g., bruising or prolonged bleeding from venipuncture) to life-threatening (e.g., GI or intracranial bleed). The exact pathologic mechanisms are not understood, but are likely multi-factorial (e.g., dysfunctional von Willebrand’s Factor (vWF) and factor VIII, increased NO, etc.)
Besides dialysis, treatments for uremic bleeding include:
Hedges, SJ. Evidence-based treatment recommendations for uremic bleeding.NatClinPractNephrol.2007 Mar;3(3):138-53.