Category: Critical Care
Keywords: thrombocytopenia, critically0ill, sepsis, death, mortality, prognosis (PubMed Search)
The incidence and prevalence of thrombocytopenia in the ICU is poorly defined however, it has been found to be an independent predictor of death in the critically-ill. Increased mortality does not appear to be related to bleeding complications. On the other hand, survivors of critical illness tend to recover platelet faster as compared to non-survivors.
Thrombocytopenia in the critically-ill is a marker for systemic inflammation/infection although the exact mechanisms are unknown. Common risk factors associated with thrombocytopenia in the ICU population are:
Bottom line: Thrombocytopenia in the critically-ill is associated with increased mortality.
Hui, P., The Frequency and Clinical Significance of Thrombocytopenia Complicating Critical Illness: A Systematic Review. Chest. 2010 Nov 11. [Epub ahead of print]