UMEM Educational Pearls

Category: Misc

Title: Dose of Epinephrine for Anaphylaxis-"Titrate to Life"

Keywords: Epinephrine (PubMed Search)

Posted: 11/15/2010 by Rob Rogers, MD (Updated: 2/23/2024)
Click here to contact Rob Rogers, MD

Dose of Epinephrine for Patients with Anaphylaxis

Many of us are familiar with 0.3-0.5 mg IM of 1:1,000. Important to give IM and not SC.

In severe cases, consider IV Epinephrine:

  • Take 1 mg of crash cart Epinephrine (1:10,000) and inject into 1 liter of normal saline
  • Start drip at 1 cc/min which is 1 microgram/min
  • "Titrate to life" (i.e. titrate up or down according to severity)


Corey Slovis, Vanderbilt University

Hans House, University of Iowa Emergency Medicine Residency,

USC Essentials Course 2010 (Mel Herbert and USC Faculty)