Neuroleptic Malignant Syndrome (NMS) is a rare, but true neurological emergency which is today associated with much lower mortality given heightened awareness about the condition.
It typically initiallybegins with muscle rigidity resulting in rhabdomyolysis, followed by high fever, and delirium.
Always check creatinine phosphokinase (CPK) and white blood cell levels when concerned about NMS, as these typically elevate in response to muscle breakdown.
The following mnemonic (FEVER) serves as a reminder of the signs and symptoms associated with NMS:
