Dapsone has been used to treat leprosy but more commonly to in brown recluse spider bites and to prevent PCP pneumonia and toxoplasmosis in our HIV population
It can cause methemoglobinemia: a reduced form of iron (ferrous to ferric) in the Hb molecule that decreases your oxygen carrying capacity.
Due to its color, cyanosis is a predominant symptom out of proportion to symptoms.
Treatment: Methylene Blue 1-2 mg/kg IV
Pitfall: Dapsone's long half-life may cause reoccurrence of MetHb and require retreatment
