Category: Critical Care
Keywords: Extubation, High Flow Nasal Cannula, Noninvasive Positive Pressure Ventilation, Airway Management (PubMed Search)
Posted: 12/6/2022 by Mark Sutherland, MD
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Although extubation has historically been the purview of critical care, as ED lengths of stay continue to worsen, and as we see more and more rapidly reversible respiratory failure (e.g. opioid overdose), it is valuable for ED providers to be facile in extubating patients. In addition, a longstanding debate in critical care has revolved around the proper device to extubate patients to, specifically: regular nasal cannula (NC) vs high flow nasal cannula (HFNC) vs noninvasive positive pressure ventilation (NIPPV). Although data are mixed, the literature suggests extubation to HFNC or NIPPV may reduce risk of reintubation, esspecially in patients at a high risk of reintubation, but doesn't show a clear difference between HFNC and NIPPV.
Hernandez et al recently conducted an RCT in two Spanish ICUs looking at HFNC vs NIPPV upon extubation for high risk patients. NIPPV was associated with a lower reintubation rate (23%) as opposed to HFNC (39%). Hospital LOS was also shorted in the NIPPV group, but no other differences were observed.
It should be noted that this study, and pretty much the entirety of this literature base, is in ICU patients. In fact, in this study, patients were excluded if they were intubated less than 24 hours. Generally speaking, patients with shorter intubation tend to be lower risk for reintubation and other post-extubation negative outcomes, so I would use caution extrapolating this too much to the ED. Unfortunately however, there is very limited literature to guide ED extubation practices.
Bottom Line:
1) Know how to assess readiness for extubation and consider extubation in the ED if they meet criteria
2) For patients at higher risk of reintubation (older, sicker, CHF, COPD, obesity, airway issues) who you are considering extubating, you may wish to extubate them to Noninvasive Positive Pressure Ventilation, even though there is little solid literature showing best practices in terms of post-extubation respiratory support in the ED.
Hernández, G., Paredes, I., Moran, F. et al. Effect of postextubation noninvasive ventilation with active humidification vs high-flow nasal cannula on reintubation in patients at very high risk for extubation failure: a randomized trial. Intensive Care Med 48, 1751–1759 (2022). https://doi.org/10.1007/s00134-022-06919-3
Yasuda, H., Okano, H., Mayumi, T. et al. Post-extubation oxygenation strategies in acute respiratory failure: a systematic review and network meta-analysis. Crit Care 25, 135 (2021). https://doi.org/10.1186/s13054-021-03550-4
