Department of Emergency Medicine

UMEM Educational Pearls

Title: Lactated Ringer's Versus 4% Albumin on Lactated Ringer's in Early Sepsis Therapy in Cancer Patients: A Pilot Single-Center Randomized Trial

Category: Critical Care

Keywords: albumin, crystalloids, sepsis (PubMed Search)

Posted: 7/25/2020 by Quincy Tran, MD, PhD (Updated: 7/28/2020)
Click here to contact Quincy Tran, MD, PhD

Patient 

  • Single Center, double-blinded, randomized trial. 

  • Patients with cancer and septic shock 

Intervention 

  • 4% albumin + lactate ringer bolus in 10 minutes 

  • 180 patients 

Comparison:  

  • Lactate ringer bolus in 10 minutes 

  • 180 patients 

Outcome:  

  • Primary: Any mortality within 7 days of randomization. 

  • Secondary: Mortality within 28 days, renal replacement therapy (RRT) 

Results: 

  • 7-day mortality: 46 (25%) for LR + albumin vs. 40 (22%) for LR only 

  • 28-day mortality: 96 (53%) for LR + albumin vs. 83 (46%) for LR only 

  • RRT: 16 (9%) for LR + albumin vs. 12 (7) for LR only 

Conclusion: 

Adding albumin for early resuscitation to crystalloids did not improve mortality in cancer patients with septic shock. 

 

References

Lactated Ringer's Versus 4% Albumin on Lactated Ringer's in Early Sepsis Therapy in Cancer Patients: A Pilot Single-Center Randomized Trial. 

Crit. Care Med. 2019 Oct;47(10):e798-e805. 

 


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