Patients with acute liver failure (ALF) frequently require rapid resuscitation to prevent decompensation and multiorgan failure.
The most common cause of ALF remains drug-induced injury (i.e., acetaminophen).
Though coagulopathy is common in patients with ALF, the prophylactic administration of blood products has not been shown to have clinical benefit.
The routine correction of coagulation abnormalities is not currently recommended, unless the patient undergoes a major procedure (e.g., liver transplant).
References
Trovato FM, et al. Update on the management of acute liver failure. Curr Opin Crit Care. 2019; 25:157-164.
