--Late awakening (>48h after sedation held) was common (78/402) in patients with cardiac arrest in prospective cohort study
--Poor prognostic signs of discontinuous (10-49% suppression) EEG and absent brain stem reflexes were independently associated with late awakening. Use of midazolam also associated with late awakening
--Late awakeners had good functional outcome when compared to early awakeners
DON'T NEUROPROGNOSTIC EARLY (OR IN ED)!
And traditional poor prognostic signs may not be as poor as previously thought!
------------------
Rey A, Rossetti AO, Miroz JP, et al. Late Awakening in Survivors of Postanoxic Coma: Early Neurophysiologic Predictors and Association With ICU and Long-Term Neurologic Recovery. Critical Care Medicine: January 2019 - Volume 47 - Issue 1 - p 85–92
